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ACT

Open Access | Routine delivery of artemisinin-based combination treatment at fixed health facilities reduces malaria prevalence in Tanzania: an observational study

May 3, 2012 - 07:52 -- Kabogo Ndegwa
Author(s): 
Khatib RA, Skarbinski J, Kachur S, et al.
Reference: 
Malaria Journal 2012, 11:140 (30 April 2012)

MalariaWorldACT is effective for treatment of uncomplicated malaria and should have substantial public health impact on morbidity and mortality, but is unlikely to reduce malaria transmission substantially in much of sub-Saharan Africa where individuals are rapidly reinfected.

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Open Access | Molecular markers in Plasmodium falciparum linked to resistance to anti-malarial drugs in samples imported from Africa over an eight-year period (2002-2010): impact of the introduction of artemisinin combination therapy

April 4, 2012 - 13:38 -- Kabogo Ndegwa
Author(s): 
Amor A, Toro C, Fernandez-Martinez A, Baquero M, Benito A, Berzosa P
Reference: 
Malaria Journal 2012, 11:100 (30 March 2012)

MalariaWorldPharmacological pressure affects the resistance strains prevalence. As for SP, the disappearance of 436A and the decrease in 540 G suggest that these mutations are not fixed.

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Malaria prevalence and treatment of febrile patients at health facilities and medicine retailers in Cameroon

February 23, 2012 - 15:29 -- Kabogo Ndegwa
Author(s): 
Lindsay J. Mangham, Bonnie Cundill, Wilfred F. Mbacham, et al.
Reference: 
Tropical Medicine & International Health, Volume 17, Issue 3, pages 330–342, March 2012

MalariaWorldMalaria case management could be improved. Symptomatic diagnosis is inefficient because two-thirds of febrile patients do not have malaria.

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Open Access | Progress towards implementation of ACT malaria case-management in public health facilities in the Republic of Sudan: a cluster- sample survey

January 6, 2012 - 13:16 -- Patrick Sampao
Author(s): 
Tarig M Abdelgader, Abdalla M Ibrahim, Khalid A Elmardi, Sophie Githinji, Dejan Zurovac, Robert W Snow and Abdisalan M Noor
Reference: 
BMC Public Health 2012, 12:11

MalariaWorldThe main outcomes were the proportions of facilities with ACTs and malaria diagnostics; proportions of health workers exposed to malaria related health systems support activities; and composite and individual indicators of case-management practices for febrile outpatients stratified by age, availability of ACTs and diagnostics, use of malaria diagnostics, and test result.

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Open Access | Adherence to a six-dose regimen of artemether-lumefantrine among uncomplicated Plasmodium falciparum patients in the Tigray Region, Ethiopia

December 6, 2011 - 08:32 -- Kabogo Ndegwa
Author(s): 
Lemma H, Lofgren C, San Sebastian M
Reference: 
Malaria Journal 2011, 10:349 (5 December 2011)

MalariaWorldThe very low adherence to AL found in this study raises serious concerns for the malaria control in the region.

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Molecular monitoring of Plasmodium falciparum resistance to antimalarial drugs after adoption of sulfadoxine–pyrimethamine plus artesunate as the first line treatment in Iran

November 17, 2011 - 11:09 -- Kabogo Ndegwa
Author(s): 
Mandana Afsharpad, Sedigheh Zakeri, Sakineh Pirahmadi, Navid Dinparast Djadid
Reference: 
Acta Tropica, Volume 121, Issue 1, January 2012, Pages 13-18

MalariaWorldThe main objective of this investigation was whether the combination therapy of sulfadoxine pyrimethamine (SP) plus artesunate (AS) protects against the spread of resistance to SP in malaria-endemic south-eastern Iran.

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Open Access | Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator

November 15, 2011 - 07:21 -- Kabogo Ndegwa
Author(s): 
Flegg JA, Guerin PJ, White NJ, Stepniewska K
Reference: 
Malaria Journal 2011, 10:339 (10 November 2011)

MalariaWorldThe parasite clearance estimator provides a consistent, reliable and accurate method to estimate the lag phase and malaria parasite clearance rate.

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Open Access | Monitoring fever treatment behaviour and equitable access to effective medicines in the context of initiatives to improve ACT access: baseline results and implications for programming in six African countries

November 2, 2011 - 08:26 -- Kabogo Ndegwa
Author(s): 
Littrell M, Gatakaa H, O'Connell KA, et al.
Reference: 
Malaria Journal 2011, 10:327 (31 October 2011)

MalariaWorldLevels of effective fever treatment are low and inequitable in many contexts.

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Open Access | Got ACTs? Availability, price, market share and provider knowledge of anti-malarial medicines in public and private sector outlets in six malaria-endemic countries

November 2, 2011 - 08:20 -- Kabogo Ndegwa
Author(s): 
O'Connell KA, Gatakaa H, Chavasse D, et al.
Reference: 
Malaria Journal 2011, 10:326 (31 October 2011)

MalariaWorldThese standardized, nationally representative results demonstrate the typically low availability, low market share and high prices of ACT, in the private sector where most anti-malarials are accessed, with some exceptions.

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Open Access | The evolution of pyrimethamine resistant dhfr in Plasmodium falciparum of south-eastern Tanzania: comparing selection under SP alone vs SP+artesunate combination

October 27, 2011 - 07:34 -- Kabogo Ndegwa
Author(s): 
Malisa AL, Pearce RJ, Mutayoba BM, Abdulla S, Mshinda H, Kachur PS, Bloland P, Roper C
Reference: 
Malaria Journal 2011, 10:317 (26 October 2011)

MalariaWorldThe study demonstrated that, alleles containing two mutations at the dhfr have arisen at least four times independently while those containing triple mutant dhfr arose only once, and were found carrying a single unique Asian-type flanking sequence, which apparently drives the spread of pyrimethamine resistance associated dhfr alleles in east Africa.

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