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Review: Toxicokinetic and toxicodynamic (TK/TD) evaluation to determine and predict the neurotoxicity of artemisinins

December 16, 2010 - 08:30 -- Patrick Sampao
Qigui Li, Mark Hickman
Toxicology, Volume 279, Issues 1-3, 11 January 2011, Pages 1-9

These findings support a recently published WHO guide for malaria treatment with artemisinin regimens, such as artemisinin-based combination therapies and injectable artesunate, to avoid neurotoxicity.

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Evaluation of the antigenicity of universal epitopes from PvDBPII in individuals exposed to Plasmodium vivax malaria

December 7, 2010 - 05:49 -- Patrick Sampao
Paola Martinez, Carolina Lopez, Carolina Saravia, Magnolia Vanegas, Manuel A. Patarroyo
Microbes and Infection, Volume 12, Issues 14-15, December 2010, Pages 1188-1197

The results suggest that conserved peptides binding with high activity to red blood cells and with known affinity to HLA-DR proteins could be good components for a P. vivax vaccine.

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