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molecules

Open Access | Oral Presentation: Progress in the development of Reversed Chloroquine molecules as antimalarial therapy

November 5, 2010 - 09:52 -- Patrick Sampao
Author(s): 
Steven J Burgess, Jane Xu-Kelly, Katherine Liebmann, Bornface Gunsaru, Westin Morrill, David H Peyton
Reference: 
Malaria Journal 2010, 9(Suppl 2):O6 (20 October 2010)

Chloroquine (CQ) resistance in P. falciparum is strongly linked to mutations in the gene pfcrt that gives rise to the protein, PfCRT (P. falciparum chloroquine resistance transporter), located in the parasite's digestive vacuole (DV) membrane [1].

Red Cells, Iron, and Erythropoiesis: Interactions with heparin-like molecules during erythrocyte invasion by Plasmodium falciparum merozoites

June 7, 2010 - 09:06 -- Patrick Sampao
Author(s): 
Michelle J. Boyle, Jack S. Richards, Paul R. Gilson, Wengang Chai, and James G. Beeson
Reference: 
Blood, Jun 2010; 115: 4559 - 4568.

All P falciparum isolates tested, and parasites using different invasion pathways were inhibited to comparable levels. Furthermore, it was not possible to select for heparin-resistant parasites. Heparin-like molecules occur naturally on the surface of human erythrocytes, where they may act as receptors for binding of merozoite surface proteins.

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