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artemisinin-based combination therapy (ACT)

Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®)

April 20, 2015 - 17:26 -- Open Access
Alfred B Tiono, Halidou Tinto, Kamal Hamed, et al.
Malaria Journal 2015, 14:157 (15 April 2015)

A three-day regimen of AL dispersible formulation was efficacious and generally well tolerated in infants weighing <5 kg with uncomplicated P. falciparum malaria, but artemether and dihydroartemisinin exposures could not be supported by the preclinical safety margins for neurotoxicity.

Medical Condition: 

Factors impeding the acceptability and use of malaria preventive measures: implications for malaria elimination in eastern Rwanda

April 1, 2015 - 07:01 -- Open Access
Chantal Ingabire, Alexis Rulisa, Luuk Van Kempen, Claude Muvunyi, Constantianus Koenraadt, Michele Van Vugt, Leon Mutesa, Bart Van Den Borne, Jane Alaii
Malaria Journal 2015, 14:136 (31 March 2015)

In this study, identification of behavioural determinants in relation to LLIN use, IRS acceptability and health care seeking is a critical step in the development of effective, targeted interventions aiming to further reduce malaria transmission and elimination in the area.

Monitoring of efficacy and safety of artemisinin-based anti-malarials for treatment of uncomplicated malaria: a review of evidence of implementation of anti-malarial therapeutic efficacy trials in Tanzania

March 31, 2015 - 17:42 -- Open Access
Alex Shayo, Joram Buza, Deus S Ishengoma
Malaria Journal 2015, 14:135 (29 March 2015)

ACT is efficacious and safe for treatment of uncomplicated malaria in Tanzania.


NOT Open Access | Antimalarial Action of Artesunate Involves DNA Damage Mediated by Reactive Oxygen Species

December 31, 2014 - 06:27 -- NOT Open Access
Anusha M. Gopalakrishnan and Nirbhay Kumar
Antimicrob. Agents Chemother. January 2015 vol. 59 no. 1 317-325

Artemisinin-based combination therapy (ACT) is the recommended first-line treatment for Plasmodium falciparum malaria.

The effect of UGTs polymorphism on the auto-induction phase II metabolism-mediated pharmacokinetics of dihydroartemisinin in healthy Chinese subjects after oral administration of a fixed combination of dihydroartemisinin-piperaquine

December 15, 2014 - 14:35 -- Open Access
Meitong Zang, Fanping Zhu, Lixia Zhao, Aijuan Yang, Xinxiu Li, Huixiang Liu, Jie Xing
Malaria Journal 2014, 13:478 (4 December 2014)

The auto-induction phase II metabolism of DHA was present in healthy Chinese subjects after the recommended two-day oral doses of DHA-PQ (Artekin).


Delayed anemia assessment in patients treated with oral artemisinin derivatives for uncomplicated malaria: a pooled analysis of clinical trials data from Mali

September 19, 2014 - 14:28 -- Open Access
Sagara I, Piarroux R, Djimde A, Giorgi R, Kayentao K, Doumbo OK, Gaudart J
Malaria Journal 2014, 13 :358 (12 September 2014)

A total of 5,990 participants were recruited and followed from day 0 to day 28.

Drugs use pattern for uncomplicated malarial in medicine retail outlets of Enugu urban, southeast Nigeria: implications for malaria treatment policy

July 3, 2014 - 11:51 -- Open Access
Ezenduka CC, Ogbonna BO, Ekwunife OI, Okonta MJ, Esimone CO
Malaria Journal 2014, 13 :243 (24 June 2014)

Findings suggest vastly improved use of ACT in the retail sector after eight years of policy change, with significant contributions from AMFm drugs.

The counterfeit anti-malarial is a crime against humanity: a systematic review of the scientific evidence

June 10, 2014 - 15:22 -- Open Access
Karunamoorthi K
Malaria Journal 2014, 13 :209 (2 June 2014)

Combating counterfeit anti-malarials is a complex task due to limited resources and poor techniques for the detection and identification of fake anti-malarials.

Designing and implementing interventions to change clinicians' practice in the management of uncomplicated malaria: lessons from Cameroon

June 10, 2014 - 12:59 -- Open Access
Achonduh OA, Mbacham WF, Wiseman V, et al.
Malaria Journal 2014, 13 :204 (29 May 2014)

Formative research was an important first step, and it was valuable to engage stakeholders early in the process.

Early parasite clearance following artemisinin-based combination therapy among Ugandan children with uncomplicated Plasmodium falciparum malaria

February 14, 2014 - 08:49 -- Open Access
Muhindo MK, Kakuru A, Jagannathan P, Talisuna A, Osilo E, Orukan F, Arinaitwe E, Tappero JW, Kaharuza F, Kamya MR, Dorsey G
Malaria Journal 2014, 13 :32 (28 January 2014)

Among Ugandan children, parasite clearance following treatment with AL or DP was excellent with only one of 752 patients tested having a positive blood slide three days after initiation of therapy.


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