A three-day regimen of AL dispersible formulation was efficacious and generally well tolerated in infants weighing <5 kg with uncomplicated P. falciparum malaria, but artemether and dihydroartemisinin exposures could not be supported by the preclinical safety margins for neurotoxicity.
artemisinin-based combination therapy (ACT)
In this study, identification of behavioural determinants in relation to LLIN use, IRS acceptability and health care seeking is a critical step in the development of effective, targeted interventions aiming to further reduce malaria transmission and elimination in the area.
ACT is efficacious and safe for treatment of uncomplicated malaria in Tanzania.
Artemisinin-based combination therapy (ACT) is the recommended first-line treatment for Plasmodium falciparum malaria.
The auto-induction phase II metabolism of DHA was present in healthy Chinese subjects after the recommended two-day oral doses of DHA-PQ (Artekin).
A total of 5,990 participants were recruited and followed from day 0 to day 28.
Findings suggest vastly improved use of ACT in the retail sector after eight years of policy change, with significant contributions from AMFm drugs.
Combating counterfeit anti-malarials is a complex task due to limited resources and poor techniques for the detection and identification of fake anti-malarials.
Formative research was an important first step, and it was valuable to engage stakeholders early in the process.
Among Ugandan children, parasite clearance following treatment with AL or DP was excellent with only one of 752 patients tested having a positive blood slide three days after initiation of therapy.