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artemisinin-based combination therapy (ACT)

Monitoring of efficacy and safety of artemisinin-based anti-malarials for treatment of uncomplicated malaria: a review of evidence of implementation of anti-malarial therapeutic efficacy trials in Tanzania

March 31, 2015 - 17:42 -- Open Access
Alex Shayo, Joram Buza, Deus S Ishengoma
Malaria Journal 2015, 14:135 (29 March 2015)

ACT is efficacious and safe for treatment of uncomplicated malaria in Tanzania.


NOT Open Access | Antimalarial Action of Artesunate Involves DNA Damage Mediated by Reactive Oxygen Species

December 31, 2014 - 06:27 -- NOT Open Access
Anusha M. Gopalakrishnan and Nirbhay Kumar
Antimicrob. Agents Chemother. January 2015 vol. 59 no. 1 317-325

Artemisinin-based combination therapy (ACT) is the recommended first-line treatment for Plasmodium falciparum malaria.

The effect of UGTs polymorphism on the auto-induction phase II metabolism-mediated pharmacokinetics of dihydroartemisinin in healthy Chinese subjects after oral administration of a fixed combination of dihydroartemisinin-piperaquine

December 15, 2014 - 14:35 -- Open Access
Meitong Zang, Fanping Zhu, Lixia Zhao, Aijuan Yang, Xinxiu Li, Huixiang Liu, Jie Xing
Malaria Journal 2014, 13:478 (4 December 2014)

The auto-induction phase II metabolism of DHA was present in healthy Chinese subjects after the recommended two-day oral doses of DHA-PQ (Artekin).


Delayed anemia assessment in patients treated with oral artemisinin derivatives for uncomplicated malaria: a pooled analysis of clinical trials data from Mali

September 19, 2014 - 14:28 -- Open Access
Sagara I, Piarroux R, Djimde A, Giorgi R, Kayentao K, Doumbo OK, Gaudart J
Malaria Journal 2014, 13 :358 (12 September 2014)

A total of 5,990 participants were recruited and followed from day 0 to day 28.

Drugs use pattern for uncomplicated malarial in medicine retail outlets of Enugu urban, southeast Nigeria: implications for malaria treatment policy

July 3, 2014 - 11:51 -- Open Access
Ezenduka CC, Ogbonna BO, Ekwunife OI, Okonta MJ, Esimone CO
Malaria Journal 2014, 13 :243 (24 June 2014)

Findings suggest vastly improved use of ACT in the retail sector after eight years of policy change, with significant contributions from AMFm drugs.

The counterfeit anti-malarial is a crime against humanity: a systematic review of the scientific evidence

June 10, 2014 - 15:22 -- Open Access
Karunamoorthi K
Malaria Journal 2014, 13 :209 (2 June 2014)

Combating counterfeit anti-malarials is a complex task due to limited resources and poor techniques for the detection and identification of fake anti-malarials.

Designing and implementing interventions to change clinicians' practice in the management of uncomplicated malaria: lessons from Cameroon

June 10, 2014 - 12:59 -- Open Access
Achonduh OA, Mbacham WF, Wiseman V, et al.
Malaria Journal 2014, 13 :204 (29 May 2014)

Formative research was an important first step, and it was valuable to engage stakeholders early in the process.

Early parasite clearance following artemisinin-based combination therapy among Ugandan children with uncomplicated Plasmodium falciparum malaria

February 14, 2014 - 08:49 -- Open Access
Muhindo MK, Kakuru A, Jagannathan P, Talisuna A, Osilo E, Orukan F, Arinaitwe E, Tappero JW, Kaharuza F, Kamya MR, Dorsey G
Malaria Journal 2014, 13 :32 (28 January 2014)

Among Ugandan children, parasite clearance following treatment with AL or DP was excellent with only one of 752 patients tested having a positive blood slide three days after initiation of therapy.

Scale-up of Malaria Rapid Diagnostic Tests and Artemisinin-Based Combination Therapy: Challenges and Perspectives in Sub-Saharan Africa

January 30, 2014 - 13:32 -- Open Access
Guido J. H. Bastiaens, Teun Bousema, Toby Leslie
PLoS Med 11(1): e1001590

An estimated 627,000 malaria deaths occurred in 2012, mostly in African children and many of them preventable with prompt diagnosis and treatment.

Increased pfmdr1 gene copy number and the decline in pfcrt and pfmdr1 resistance alleles in Ghanaian Plasmodium falciparum isolates after the change of anti-malarial drug treatment policy

November 6, 2013 - 08:04 -- Open Access
Duah NO, Matrevi SA, de Souza DK, Binnah DD, Tamakloe MM, Opoku VS, Onwona CO, Narh CA, Quashie NB, Abuaku B, Duplessis C, Kronmann KC, Koram KA
Malaria Journal 2013, 12 :377 (30 October 2013)

Increased pfmdr1 gene copy number was observed in the isolates analysed and this finding has implications for the use of ACT in the country although no resistance has been reported.


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