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artemisinin-based combination therapy (ACT)

Provider compliance to artemisinin-based combination therapy at primary health care facilities in the middle belt of Ghana

September 23, 2015 - 16:49 -- Open Access
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Author(s): 
Anthony Kwarteng, Kwaku Asante, Seth Owusu-Agyei, et al.
Reference: 
Malaria Journal 2015, 14:361 (22 September 2015)

Although the majority of patients presenting with malaria received treatment according to the national malaria guidelines, there were widespread inappropriate treatment with ACT.

Effectiveness and safety of artemether–lumefantrine versus artesunate–amodiaquine for unsupervised treatment of uncomplicated falciparum malaria in patients of all age groups in Nanoro, Burkina Faso: a randomized open label trial

August 25, 2015 - 06:04 -- Open Access
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Author(s): 
Paul Sondo, Karim Derra, Halidou Tinto, et al.
Reference: 
Malaria Journal 2015, 14:325 (20 August 2015)

This study shows a lowering of the efficacy when drug intake is not directly supervised.

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Development of a text-messaging intervention to improve treatment adherence and post-treatment review of children with uncomplicated malaria in western Kenya

August 24, 2015 - 17:36 -- Open Access
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Author(s): 
Sophie Githinji, Caroline Jones, Josephine Malinga, Robert W Snow, Ambrose Talisuna, Dejan Zurovac
Reference: 
Malaria Journal 2015, 14:320 (19 August 2015)

Text message interventions should be carefully developed, tested and refined before implementation to ensure they are written in the most appropriate way for their target population.

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NOT Open Access | Tailoring a Pediatric Formulation of Artemether-Lumefantrine for Treatment of Plasmodium falciparum Malaria

July 22, 2015 - 10:15 -- NOT Open Access
Author(s): 
Quique Bassat, Bernhards Ogutu, Abdoulaye Djimde, Kirstin Stricker, and Kamal Hamed
Reference: 
Antimicrob. Agents Chemother. August 2015 vol. 59 no. 8 4366-4374

Specially created pediatric formulations have the potential to improve the acceptability, effectiveness, and accuracy of dosing of artemisinin-based combination therapy (ACT) in young children, a patient group that is inherently vulnerable to malaria.

Past and new challenges for malaria control and elimination: the role of operational research for innovation in designing interventions

July 17, 2015 - 10:39 -- Open Access
Author(s): 
Philippe Guyant, Vincent Corbel, Nicholas White, et al.
Reference: 
Malaria Journal 2015, 14:279 (17 July 2015)

This meeting report presents the outcomes of a workshop held in Bangkok on December 1st 2014, where the following challenges were discussed: the threat of resistance to artemisinin and artemisinin-based combination therapy in the Greater Mekong Sub-region (GMS) and in Africa; access to treatment for most at risk and hard to reach population; insecticide resistance, residual and outdoors transmission.

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Availability and quality of anti-malarials among private sector outlets in Myanmar in 2012: results from a large, community-based, cross-sectional survey before a large-scale intervention

July 14, 2015 - 09:22 -- Open Access
Author(s): 
Hnin Khin, Ingrid Chen, Chris White, May Sudhinaraset, Willi McFarland, Megan Littrell, Dominic Montagu, Tin Aung
Reference: 
Malaria Journal 2015, 14:269 (14 July 2015)

Informal private pharmacies, itinerant drug vendors and general retailers should be targeted for interventions to improve malaria treatment practices in Myanmar, particularly those that threaten the emergence and spread of artemisinin resistance.

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NOT Open Access | Plasmodium falciparum population structure in Sudan post artemisinin-based combination therapy

June 23, 2015 - 06:39 -- NOT Open Access
Author(s): 
Amani M.A. Bakhiet, Abdel-Muhsin A. Abdel-Muhsin, Hamza A. Babiker, et al.
Reference: 
Acta Tropica, Volume 148, August 2015, Pages 97–104

Despite marked reduction in malaria risk in Sudan, the extent of diversity and parasite genetic structure are indicative of a large population size.

Impact of rapid diagnostic tests for the diagnosis and treatment of malaria at a peripheral health facility in Western Uganda: an interrupted time series analysis

May 18, 2015 - 12:51 -- Open Access
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Author(s): 
Ross M Boyce, Anthony Muiru, Raquel Reyes, Moses Ntaro, Edgar Mulogo, Michael Matte, Mark J Siedner
Reference: 
Malaria Journal 2015, 14:203 (15 May 2015)

This study is one of the few to demonstrate significant improvement in clinical outcomes and process measures following the introduction of RDTs for the diagnosis of malaria at a rural health facility in Uganda.

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Malaria Care in Infants Aged under Six Months in Uganda: An Area of Unmet Needs!

April 24, 2015 - 06:49 -- Open Access
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Author(s): 
Martin Kayitale Mbonye, Sarah M. Burnett, Sarah Naikoba, Robert Colebunders, Kristien Wouters, Marcia R. Weaver, Jean Pierre Van Geertruyden
Reference: 
PLoS ONE 10(4): e0123283

We found high malaria suspicion but low testing rates in outpatient children aged <6 months. Among those tested, MPPR was high.

Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®)

April 20, 2015 - 17:26 -- Open Access
Author(s): 
Alfred B Tiono, Halidou Tinto, Kamal Hamed, et al.
Reference: 
Malaria Journal 2015, 14:157 (15 April 2015)

A three-day regimen of AL dispersible formulation was efficacious and generally well tolerated in infants weighing &lt;5 kg with uncomplicated P. falciparum malaria, but artemether and dihydroartemisinin exposures could not be supported by the preclinical safety margins for neurotoxicity.

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