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artemisinin-based combination therapy (ACT)

Failure of dihydroartemisinin plus piperaquine treatment of falciparum malaria by under-dosing in an overweight patient

September 21, 2016 - 17:39 -- Open Access
Author(s): 
Jean Baptiste Roseau, Bruno Pradines, Nicolas Paleiron, Serge Vedy, Marylin Madamet, Fabrice Simon and Emilie Javelle
Reference: 
Malaria Journal 2016 15:479, 20 September 2016

This case confirms the risk of therapeutic failure with dihydroartemisinin–piperaquine by under-dosing in patients weighing more than 100 kg.

Probucol dramatically enhances dihydroartemisinin effect in murine malaria

September 21, 2016 - 17:15 -- Open Access
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Author(s): 
Aiko Kume, Dang Trinh Minh Anh, Mototada Shichiri, Noriko Ishida and Hiroshi Suzuki
Reference: 
Malaria Journal 2016 15:472, 15 September 2016

This study demonstrated that probucol has some impact on malaria by oxidative stress through the induction of host plasma vitamin E deficiency.

Assets and challenges facing caregivers when managing malaria in young children in rural Uganda

September 14, 2016 - 17:18 -- Open Access
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Author(s): 
Rosemin Kassam, John Collins and Richard Sekiwunga
Reference: 
Malaria Journal 2016 15:467, 13 September 2016

Findings from this study suggest that the low use of artemisinin-based combination therapy (ACT) in Butaleja for children 5 years and under may result from caregivers’ high perceived barrier to accessing ACT and low perceived benefits from ACT.

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Adding a single low-dose of primaquine (0.25 mg/kg) to artemether-lumefantrine did not compromise treatment outcome of uncomplicated Plasmodium falciparum malaria in Tanzania: a randomized, single-blinded clinical trial

August 30, 2016 - 15:08 -- Open Access
Author(s): 
Richard Mwaiswelo, Billy Ngasala, Irina Jovel, Berit Aydin-Schmidt, Roland Gosling, Zul Premji, Bruno Mmbando, Anders Björkman and Andreas Mårtensson
Reference: 
Malaria Journal 2016 15:435, 26 August 2016

The new WHO recommendation of adding a single low-dose of PQ to AL did not compromise treatment outcome of uncomplicated P. falciparum malaria in Tanzania.

In vitro selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemisinin

July 27, 2016 - 07:19 -- Open Access
Author(s): 
Muturi J. Njokah, Joseph N. Kang’ethe, Johnson Kinyua, Daniel Kariuki and Francis T. Kimani
Reference: 
Malaria Journal 2016 15:381, 22 July 2016

Artemisinin resistance phenotype as has been shown in this work, is a decrease in parasites susceptibility to artemisinin derivatives together with the parasite’s ability to recover from drug-induced dormancy after exposure to drug dosage above the in vivo clinical concentrations.

Organization: 

The role of early detection and treatment in malaria elimination

July 19, 2016 - 16:20 -- Open Access
Author(s): 
Jordi Landier, Daniel M. Parker, François H. Nosten, et al.
Reference: 
Malaria Journal 2016 15:363, 15 July 2016

Falciparum malaria persists in hard-to-reach areas or demographic groups that are missed by conventional healthcare systems but could be reached by trained community members in a malaria post (MP).

A cross-sectional study of the availability and price of anti-malarial medicines and malaria rapid diagnostic tests in private sector retail drug outlets in rural Western Kenya, 2013

July 19, 2016 - 15:45 -- Open Access
Author(s): 
Urbanus Kioko, Christina Riley, Ann M. Buff, et al.
Reference: 
Malaria Journal 2016 15:359, 12 July 2016

Most outlets never stocked RDTs; therefore, testing prior to treatment was unlikely for customers seeking treatment in the private retail sector.

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Prevalence of anti-malarial resistance genes in Dakar, Senegal from 2013 to 2014

July 12, 2016 - 16:56 -- Open Access
Author(s): 
Agathe Boussaroque, Bécaye Fall, Bruno Pradines, et al.
Reference: 
Malaria Journal 2016 15:347, 7 July 2016

Despite a decline in the prevalence of chloroquine resistance due to the official withdrawal of the drug and to the introduction of ACT, the spread of resistance to chloroquine has continued.

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Impact of using artemisinin-based combination therapy (ACT) in the treatment of uncomplicated malaria from Plasmodium falciparum in a non-endemic zone

July 5, 2016 - 18:40 -- Open Access
Author(s): 
Joaquín Pousibet-Puerto, Joaquín Salas-Coronas, M. Teresa Cabezas-Fernández, et al.
Reference: 
Malaria Journal 2016 15:339, 2 July 2016

ACT treatment of admitted hospital patients with imported uncomplicated malaria from P. falciparum reduced the days spent hospitalized as well as producing a more rapid parasite clearance compared to classic treatment.

Who continues to stock oral artemisinin monotherapy? Results of a provider survey in Myanmar

June 28, 2016 - 16:52 -- Open Access
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Author(s): 
Si Thu Thein, May Sudhinaraset, Hnin Su Su Khin, Willi McFarland and Tin Aung
Reference: 
Malaria Journal 2016 15:334, 22 June 2016

Private healthcare facilities and drug shops and providers who prioritize consumers’ demand instead of recommended practices were more likely to stock oral AMT.

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