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artemisinin-based combination therapy (ACT)

Factors associated with non-adherence to Artemisinin-based Combination Therapy (ACT) to malaria in a rural population from holoendemic region of western Kenya

June 25, 2012 - 13:06 -- Patrick Sampao
Author(s): 
Onyango EO, Ayodo G, Watsierah CA, Were T, Okumu W, Anyona SB, Raballah E, Okoth JM, Gumo S, Orinda GO, Ouma C
Reference: 
BMC Infectious Diseases 2012, 12:143 (24 June 2012)

MalariaWorldThis study demonstrates that more than half of those who get ACT prescription do not take recommended dose and that accessibility is of concern.

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Open Access | A systematic review of the safety and efficacy of artemether-lumefantrine against uncomplicated Plasmodium falciparum malaria during pregnancy

May 3, 2012 - 08:03 -- Kabogo Ndegwa
Author(s): 
Manyando C, Kayentao K, D'Alessandro U, Okafor HU, Juma E, Hamed K
Reference: 
Malaria Journal 2012, 11:141 (1 May 2012)

MalariaWorldMalaria during pregnancy, particularly Plasmodium falciparum malaria, has been linked to increased morbidity and mortality, which must be reduced by both preventive measures and effective case management.

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Open Access | Glucose-6-phosphate dehydrogenase deficiency, chlorproguanil-dapsone with artesunate and post-treatment haemolysis in African children treated for uncomplicated malaria

May 3, 2012 - 07:15 -- Kabogo Ndegwa
Author(s): 
Van Malderen C, Van geertruyden J, D'Alessandro U, et al.
Reference: 
Malaria Journal 2012, 11:139 (30 April 2012)

MalariaWorldThe use of CDA for treating uncomplicated malaria may increase the risk of haemolytic anaemia in G6PD-deficient children.

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Open Access | Artemisinin-based combination therapy does not measurably reduce human infectiousness to vectors in a setting of intense malaria transmission

April 26, 2012 - 12:44 -- Kabogo Ndegwa
Author(s): 
Huho BJ, Killeen GF, Ferguson HM, Tami A, Lengeler C, Charlwood J, Kihonda A, Kihonda J, Kachur S, Smith TA, Abdulla SM
Reference: 
Malaria Journal 2012, 11:118 (18 April 2012)

MalariaWorldIn high perennial transmission settings, only a small proportion of infections in humans are symptomatic or treated, so case management with ACT may have little impact on overall infectiousness of the human population.

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Open Access | Relationship between treatment-seeking behaviour and artemisinin drug quality in Ghana

April 11, 2012 - 06:52 -- Kabogo Ndegwa
Author(s): 
Klein EY, Lewis IA, Jung C, Llinas M, Levin SA
Reference: 
Malaria Journal 2012, 11:110 (6 April 2012)

MalariaWorldSurprisingly, drug quality was found to be uniformly high and thus no significant relationship between price, treatment-seeking behaviour and the content of the active ingredients was observed.

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Open Access | Artesunate-amodiaquine fixed dose combination for the treatment of Plasmodium falciparum malaria in India

April 4, 2012 - 12:09 -- Kabogo Ndegwa
Author(s): 
Anvikar AR, Sharma B, Shahi BH, Tyagi PK, Bose TK, Sharma SK, Srivastava P, Srivastava B, Kiechel JR, Dash AP, Valecha N
Reference: 
Malaria Journal 2012, 11:97 (30 March 2012)

MalariaWorldThe fixed dose combination of ASAQ was found to be efficacious and safe treatment for P. falciparum malaria.

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Open Access | History of malaria research and its contribution to the malaria control success in Suriname: a review

April 4, 2012 - 06:32 -- Kabogo Ndegwa
Author(s): 
Breeveld FJ, Vreden SG, Grobusch MP
Reference: 
Malaria Journal 2012, 11:95 (29 March 2012)

MalariaWorldSuriname has cleared malaria from its capital city and coastal areas mainly through the successful use of chloroquine and DDT (dichloro-diphenyl-trichloroethane) during the Global Malaria Eradication programme that started in 1955.

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Open Access | Exploring provider and community responses to the new malaria diagnostic and treatment regime in Solomon Islands

January 12, 2011 - 10:36 -- Kabogo Ndegwa
Author(s): 
Wijesinghe RS, Atkinson JM, Bobogare A, Wini L, Whittaker M
Reference: 
Malaria Journal 2011, 10:3 (10 January 2011)

To address these issues, further training and supportive supervision of healthcare workers will be essential, as will the engagement of influential community members in health promotion activities to improve acceptability of RDTs and adherence to the new treatment regime.

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Open Access | Plasmodium falciparum clearance with artemisinin-based combination therapy (ACT) in patients with glucose-6-phosphate dehydrogenase deficiency in Mali

November 24, 2010 - 09:18 -- Kabogo Ndegwa
Author(s): 
Abdoulaye K. Kone, Issaka Sagara, Mahamadou A. Thera, Alassane Dicko, Aldiouma Guindo, Seidina Diakite, Joseph Kurantsin-Mills, Abdoulaye Djimde, Asikiya Walcourt, Ogobara K. Doumbo
Reference: 
Malaria Journal 2010, 9:332 (21 November 2010)

The presence of G6PD deficiency does not appear to significantly influence the clearance of P. falciparum in the treatment of uncomplicated malaria using ACT.

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Open Access | The quest for universal access to effective malaria treatment: how can the AMFm contribute?

October 13, 2010 - 09:24 -- Kabogo Ndegwa
Tags: 
Author(s): 
Matowe L, Adeyi O
Reference: 
Malaria Journal 2010, 9:274 (8 October 2010)

Access to quality assured artemisinin-based combination therapy (ACT) has remained very low in most malaria endemic countries. A number of reasons, including unaffordable prices, have contributed to the low accessibility to these life-saving medicines.

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