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artemisinin-based combination therapy (ACT)

Another challenge in malaria elimination efforts: the increase of malaria among adults after the implementation of long-lasting insecticide-treated nets (LLINs) in Dielmo, Senegal

October 30, 2018 - 15:39 -- Open Access
Author(s): 
Amélé N. Wotodjo, Souleymane Doucoure, Nafissatou Diagne, Fatoumata Diene Sarr, Philipe Parola, Jean Gaudart and Cheikh Sokhna
Reference: 
Malaria Journal 2018 17:384, 25 October 2018

Malaria among adults especially younger adults should deserve more attention in the areas where malaria was previously endemic as they became vulnerable probably because of the partial acquisition and—or—the loss of anti-Plasmodium relative immunity and the non regular use of LLINs.

Investigating the Efficacy of Triple Artemisinin-Based Combination Therapies for Treating Plasmodium falciparum Malaria Patients Using Mathematical Modeling

October 30, 2018 - 12:46 -- Open Access
Author(s): 
Saber Dini, Sophie Zaloumis, Pengxing Cao, Ric N. Price, Freya J. I. Fowkes, Rob W. van der Pluijm, James M. McCaw and Julie A. Simpson
Reference: 
Antimicrob. Agents Chemother. November 2018 62:e01068-18

The first line treatment for uncomplicated falciparum malaria is artemisinin-based combination therapy (ACT), which consists of an artemisinin derivative coadministered with a longer-acting partner drug.

Efficacy and safety of artemisinin-based combination therapy, and molecular markers for artemisinin and piperaquine resistance in Mainland Tanzania

October 20, 2018 - 10:02 -- Open Access
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Author(s): 
Mwaka A. Kakolwa, Muhidin K. Mahende, Abdunoor M. Kabanywanyi, et al.
Reference: 
Malaria Journal 2018 17:369, 17 October 2018

All the tested ACT in mainland Tanzania were highly efficacious and none of validated k13 mutants associated with artemisinin resistance was observed.

The quality of anti-malarial medicines in Embu County, Kenya

September 18, 2018 - 16:11 -- Open Access
Tags: 
Author(s): 
Stanley Ndwigah, Andy Stergachis, Kennedy Abuga, Hannington Mugo and Isaac Kibwage
Reference: 
Malaria Journal 2018 17:330, 15 September 2018

All the anti-malarial drugs analysed in this study passed the quality control tests.

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Imported and autochthonous malaria in West Saudi Arabia: results from a reference hospital

August 7, 2018 - 15:34 -- Open Access
Author(s): 
Rasha Hassan Soliman, Patricia Garcia-Aranda, Sherine Mohamed Elzagawy, Boshra El-Sayed Hussein, Wael Wahid Mayah, Alexandra Martin Ramirez, Thuy-Huong Ta-Tang and José Miguel Rubio
Reference: 
Malaria Journal 2018 17:286, 7 August 2018

Haplotypes of P. falciparum in the western region of the Kingdom of Saudi Arabia exhibit high resistance against antifolate drugs.

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Efficacy of artesunate–amodiaquine in the treatment of falciparum uncomplicated malaria in Madagascar

August 7, 2018 - 15:24 -- Open Access
Author(s): 
Oméga Raobela, Valérie Andriantsoanirina, David Gael Rajaonera, Tovonahary Angelo Rakotomanga, Stéphane Rabearimanana, Fanomezantsoa Ralinoro, Didier Ménard and Arsène Ratsimbasoa
Reference: 
Malaria Journal 2018 17:284, 6 August 2018

The ASAQ combination remains highly effective for the treatment of uncomplicated falciparum malaria in Madagascar.

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High efficacy of artemether–lumefantrine and dihydroartemisinin–piperaquine for the treatment of uncomplicated falciparum malaria in Muheza and Kigoma Districts, Tanzania

July 15, 2018 - 16:54 -- Open Access
Author(s): 
Celine I. Mandara, Reginald A. Kavishe, Deus S. Ishengoma, et al.
Reference: 
Malaria Journal 2018 17:261, 11 July 2018

These findings confirm high efficacy of the first- and the newly recommended alternative ACT for treatments for uncomplicated falciparum malaria in Tanzania.

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Efficacy of two artemisinin-based combinations for the treatment of malaria in pregnancy in India: a randomized controlled trial

July 6, 2018 - 15:54 -- Open Access
Author(s): 
Anupkumar R. Anvikar, Irene Kuepfer, Neena Valecha, et al.
Reference: 
Malaria Journal 2018 17:246, 4 July 2018

Both AS+SP and AS+MQ are safe and effective for treatment of uncomplicated falciparum malaria in pregnancy in India.

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Reduction of malaria prevalence after introduction of artemisinin-combination-therapy in Mbeya Region, Tanzania: results from a cohort study with 6773 participants

June 26, 2018 - 16:31 -- Open Access
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Author(s): 
Guenter Froeschl, Elmar Saathoff, Michael Hoelscher, et al.
Reference: 
Malaria Journal 2018 17:245, 26 June 2018

The longitudinal study showed a significant and relevant decline in the prevalence of P. falciparum infection after introduction of ACT, which could not be explained by potential confounders

The decline of malaria in Vietnam, 1991–2014

June 13, 2018 - 08:25 -- Open Access
Tags: 
Author(s): 
Sandra M. Goldlust, Phung Duc Thuan, Tran Tinh Hien, et al.
Reference: 
Malaria Journal 2018 17:226, 7 June 2018

The decline of malaria in Vietnam can largely be attributed to the adoption of artemisinin-based case management.

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