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artemisinin-based combination therapy (ACT)

Population pharmacokinetics and pharmacodynamics of the artesunate–mefloquine fixed dose combination for the treatment of uncomplicated falciparum malaria in African children

April 22, 2019 - 12:28 -- Open Access
Author(s): 
Monia Guidi, Thomas Mercier, Manel Aouri, Laurent A. Decosterd, Chantal Csajka, Bernhards Ogutu, Gwénaëlle Carn and Jean-René Kiechel
Reference: 
Malaria Journal 2019 18:139, 18 April 2019

The population pharmacokinetic models developed for both AS/DHA and MQ showed a large variability in drug exposure in the investigated African paediatric population.

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Artemisinin-based combination therapy during pregnancy: outcome of pregnancy and infant mortality: a cohort study

March 28, 2019 - 16:32 -- Open Access
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Author(s): 
Michael Nambozi, Halidou Tinto, Umberto D’Alessandro, et al.
Reference: 
Malaria Journal 2019 18:105, 28 March 2019

Outcome of pregnancy and infant survival were similar between treatment arms indicating that any of the four artemisinin-based combinations could be safely used during the second and third trimester of pregnancy without any adverse effect on the baby.

The past, present and future of anti-malarial medicines

March 26, 2019 - 15:56 -- Open Access
Author(s): 
Edwin G. Tse, Marat Korsik and Matthew H. Todd
Reference: 
Malaria Journal 2019 18:93, 22 March 2019

Great progress has been made in recent years to reduce the high level of suffering caused by malaria worldwide.

Prescribing patterns and compliance with World Health Organization recommendations for the management of severe malaria: a modified cohort event monitoring study in public health facilities in Ghana and Uganda

February 13, 2019 - 16:13 -- Open Access
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Author(s): 
H. Hilda Ampadu, Kwaku Poku Asante, Samuel Bosomprah, Samantha Akakpo, Pierre Hugo, Helga Gardarsdottir, Hubert G. M. Leufkens, Dan Kajungu and Alexander N. O. Dodoo
Reference: 
Malaria Journal 2019 18:36, 8 February 2019

Injectable AS is the most commonly prescribed medicine in the management of severe malaria in Ghana and Uganda.

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Does artemether–lumefantrine administration affect mosquito olfactory behaviour and fitness?

January 30, 2019 - 16:08 -- Open Access
Author(s): 
Jetske G. de Boer, Annette O. Busula, Jet ten Berge, Tessa S. van Dijk and Willem Takken
Reference: 
Malaria Journal 2019 18:28, 28 January 2019

Based on the results, AL does not appear to influence malaria transmission through modification of vector mosquito olfactory behaviour or fitness.

An online mapping database of molecular markers of drug resistance in Plasmodium falciparum: the ACT Partner Drug Molecular Surveyor

January 22, 2019 - 14:56 -- Open Access
Author(s): 
Sabina Dahlström Otienoburu, Ignacio Suay, Steven Garcia, Nigel V. Thomas, Suttipat Srisutham, Anders Björkman and Georgina S. Humphreys
Reference: 
Malaria Journal 2019 18:12, 18 January 2019

The WWARN ACT Partner Drugs Molecular Surveyor summarizes data on resistance markers in the pfmdr1 and pfcrt genes.

Measuring malaria diagnosis and treatment coverage in population-based surveys: a recall validation study in Mali among caregivers of febrile children under 5 years

January 8, 2019 - 15:24 -- Open Access
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Author(s): 
Ruth A. Ashton, Bakary Doumbia, Thomas P. Eisele, et al.
Reference: 
Malaria Journal 2019 18:3, 3 January 2019

These findings indicate that caregivers’ responses during household surveys are valid when assessing if a child received a finger/heel prick during a consultation in the previous 2 weeks, and if the malaria test result was positive.

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Has doxycycline, in combination with anti-malarial drugs, a role to play in intermittent preventive treatment of Plasmodium falciparum malaria infection in pregnant women in Africa?

December 27, 2018 - 15:22 -- Open Access
Author(s): 
Tiphaine Gaillard, Manon Boxberger, Marylin Madamet and Bruno Pradines
Reference: 
Malaria Journal 2018 17:469, 14 December 2018

According to the World Health Organization (WHO), Plasmodium falciparum malaria during pregnancy is responsible for deleterious consequences for the mother and her child.

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Another challenge in malaria elimination efforts: the increase of malaria among adults after the implementation of long-lasting insecticide-treated nets (LLINs) in Dielmo, Senegal

October 30, 2018 - 15:39 -- Open Access
Author(s): 
Amélé N. Wotodjo, Souleymane Doucoure, Nafissatou Diagne, Fatoumata Diene Sarr, Philipe Parola, Jean Gaudart and Cheikh Sokhna
Reference: 
Malaria Journal 2018 17:384, 25 October 2018

Malaria among adults especially younger adults should deserve more attention in the areas where malaria was previously endemic as they became vulnerable probably because of the partial acquisition and—or—the loss of anti-Plasmodium relative immunity and the non regular use of LLINs.

Investigating the Efficacy of Triple Artemisinin-Based Combination Therapies for Treating Plasmodium falciparum Malaria Patients Using Mathematical Modeling

October 30, 2018 - 12:46 -- Open Access
Author(s): 
Saber Dini, Sophie Zaloumis, Pengxing Cao, Ric N. Price, Freya J. I. Fowkes, Rob W. van der Pluijm, James M. McCaw and Julie A. Simpson
Reference: 
Antimicrob. Agents Chemother. November 2018 62:e01068-18

The first line treatment for uncomplicated falciparum malaria is artemisinin-based combination therapy (ACT), which consists of an artemisinin derivative coadministered with a longer-acting partner drug.

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