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artemisinin-based combination therapy (ACT)

Quality of fixed dose artemether/lumefantrine products in Jimma Zone, Ethiopia

July 15, 2019 - 16:14 -- Open Access
Author(s): 
Sileshi Belew, Sultan Suleman, Bart De Spiegeleer, et al.
Reference: 
Malaria Journal 2019 18:236, 15 July 2019

Malaria caused by Plasmodium vivax and Plasmodium falciparum is among the major public health problems in most endemic areas of the world. Artemisinin-based combination therapy (ACT) has been recommended as a first-line treatment for uncomplicated Plasmodium falciparum malaria almost in all endemic regions. Since ineffectively regulated medicines in resource limited settings could favour infiltration of poor quality anti-malarial medicines into pharmaceutical supply chain and jeopardize a positive treatment outcome, regular monitoring of the quality of anti-malarial medicines is critical. Thus, the aim of this study was to assess the quality of fixed dose combination (FDC) artemether (ART)/lumefantrine (LUM) tablets available in Jimma zone, Ethiopia.

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Therapeutic efficacy of artesunate–amodiaquine and artemether–lumefantrine combinations for uncomplicated malaria in 10 sentinel sites across Ghana: 2015–2017

June 24, 2019 - 16:00 -- Open Access
Author(s): 
Benjamin Abuaku, Nancy O. Duah-Quashie, Lydia Quaye, Sena A. Matrevi, Neils Quashie, Akosua Gyasi, Felicia Owusu-Antwi, Keziah Malm and Kwadwo Koram
Reference: 
Malaria Journal 2019 18:206, 24 June 2019

Routine surveillance on the therapeutic efficacy of artemisinin-based combination therapy (ACT) has been ongoing in Ghana since 2005. The sixth round of surveillance was conducted between 2015 and 2017 to determine the therapeutic efficacy of artesunate–amodiaquine (AS–AQ) and artemether–lumefantrine (AL) in 10 sentinel sites across the country.

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Population pharmacokinetics and pharmacodynamics of the artesunate–mefloquine fixed dose combination for the treatment of uncomplicated falciparum malaria in African children

April 22, 2019 - 12:28 -- Open Access
Author(s): 
Monia Guidi, Thomas Mercier, Manel Aouri, Laurent A. Decosterd, Chantal Csajka, Bernhards Ogutu, Gwénaëlle Carn and Jean-René Kiechel
Reference: 
Malaria Journal 2019 18:139, 18 April 2019

The population pharmacokinetic models developed for both AS/DHA and MQ showed a large variability in drug exposure in the investigated African paediatric population.

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Artemisinin-based combination therapy during pregnancy: outcome of pregnancy and infant mortality: a cohort study

March 28, 2019 - 16:32 -- Open Access
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Author(s): 
Michael Nambozi, Halidou Tinto, Umberto D’Alessandro, et al.
Reference: 
Malaria Journal 2019 18:105, 28 March 2019

Outcome of pregnancy and infant survival were similar between treatment arms indicating that any of the four artemisinin-based combinations could be safely used during the second and third trimester of pregnancy without any adverse effect on the baby.

The past, present and future of anti-malarial medicines

March 26, 2019 - 15:56 -- Open Access
Author(s): 
Edwin G. Tse, Marat Korsik and Matthew H. Todd
Reference: 
Malaria Journal 2019 18:93, 22 March 2019

Great progress has been made in recent years to reduce the high level of suffering caused by malaria worldwide.

Prescribing patterns and compliance with World Health Organization recommendations for the management of severe malaria: a modified cohort event monitoring study in public health facilities in Ghana and Uganda

February 13, 2019 - 16:13 -- Open Access
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Author(s): 
H. Hilda Ampadu, Kwaku Poku Asante, Samuel Bosomprah, Samantha Akakpo, Pierre Hugo, Helga Gardarsdottir, Hubert G. M. Leufkens, Dan Kajungu and Alexander N. O. Dodoo
Reference: 
Malaria Journal 2019 18:36, 8 February 2019

Injectable AS is the most commonly prescribed medicine in the management of severe malaria in Ghana and Uganda.

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Does artemether–lumefantrine administration affect mosquito olfactory behaviour and fitness?

January 30, 2019 - 16:08 -- Open Access
Author(s): 
Jetske G. de Boer, Annette O. Busula, Jet ten Berge, Tessa S. van Dijk and Willem Takken
Reference: 
Malaria Journal 2019 18:28, 28 January 2019

Based on the results, AL does not appear to influence malaria transmission through modification of vector mosquito olfactory behaviour or fitness.

An online mapping database of molecular markers of drug resistance in Plasmodium falciparum: the ACT Partner Drug Molecular Surveyor

January 22, 2019 - 14:56 -- Open Access
Author(s): 
Sabina Dahlström Otienoburu, Ignacio Suay, Steven Garcia, Nigel V. Thomas, Suttipat Srisutham, Anders Björkman and Georgina S. Humphreys
Reference: 
Malaria Journal 2019 18:12, 18 January 2019

The WWARN ACT Partner Drugs Molecular Surveyor summarizes data on resistance markers in the pfmdr1 and pfcrt genes.

Measuring malaria diagnosis and treatment coverage in population-based surveys: a recall validation study in Mali among caregivers of febrile children under 5 years

January 8, 2019 - 15:24 -- Open Access
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Author(s): 
Ruth A. Ashton, Bakary Doumbia, Thomas P. Eisele, et al.
Reference: 
Malaria Journal 2019 18:3, 3 January 2019

These findings indicate that caregivers’ responses during household surveys are valid when assessing if a child received a finger/heel prick during a consultation in the previous 2 weeks, and if the malaria test result was positive.

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Has doxycycline, in combination with anti-malarial drugs, a role to play in intermittent preventive treatment of Plasmodium falciparum malaria infection in pregnant women in Africa?

December 27, 2018 - 15:22 -- Open Access
Author(s): 
Tiphaine Gaillard, Manon Boxberger, Marylin Madamet and Bruno Pradines
Reference: 
Malaria Journal 2018 17:469, 14 December 2018

According to the World Health Organization (WHO), Plasmodium falciparum malaria during pregnancy is responsible for deleterious consequences for the mother and her child.

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