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New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides

February 25, 2010 - 21:46 -- Kabogo Ndegwa
Satoru Tamura, Bruno Kilunga Kubata, Syamsurizal, Sawako Itagaki, Toshihiro Horii, Muzele Kalulu Taba, Nobutoshi Murakami
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 5, 1 March 2010, Pages 1520-1523

A new phenylpropanoid conjugated iridoid together with four known congeners was isolated from Morinda morindoides, used for the therapy of malaria traditionally in some African countries, as anti-malarial principles through bioassay-guided separation.


Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents

February 5, 2010 - 16:46 -- Ingeborg van Schayk
Devdutt Chaturvedi, Abhishek Goswami, Partha Pratim Saikia, Nabin C. Barua and Paruchuri G. Rao
Chem. Soc. Rev., 2010, 39, 435 - 454

It is expected that this review will provide first-hand information on artemisinin chemistry to organic/medicinal chemists, and pharmacologists working on anticancer and anti-malarial drug development.

Open Access | IL4 gene polymorphism and previous malaria experiences manipulate anti-Plasmodium falciparum antibody isotype profiles in complicated and uncomplicated malaria

December 14, 2009 - 11:49 -- Ingeborg van Schayk
Piyatida Tangteerawatana, Hedvig Perlmann, Masashi Hayano, Thareerat Kalambaheti, Marita Troye-Blomberg, Srisin Khusmith
Malaria Journal 2009, 8:286 (10 December 2009)

The results suggest that IL4-590C or T alleles participated differently in the regulation of anti-malarial antibody isotype profiles in primary and secondary malaria infection and, therefore, could play an important role in alteration of malaria severity.

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Bioassay-guided fractionation and in vivo antiplasmodial effect of fractions of chloroform extract of Artemisia maciverae Linn

October 31, 2009 - 09:43 -- Ingeborg van Schayk
A.C. Ene, S.E. Atawodi, D.A. Ameh, G.I. Ndukwe, H.O. Kwanashie
Acta Tropica, Volume 112, Issue 3, December 2009, Pages 288-294,doi:10.1016/j.actatropica.2009.08.016

In the search for new plant-derived anti-malarial compounds, chromatographic fractions of chloroform extract of whole plants of Artemisia maciverae were tested in vivo using chloroquine resistant and chloroquine sensitive Plasmodium berghei NK 65 infected Swiss albino mice.

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