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anti-malarial

Open Access | Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: a bioassay-guided fractionation of the stem bark

June 21, 2011 - 13:01 -- Kabogo Ndegwa
Author(s): 
Zofou D, Kowa TK, Wabo HK, Ngemenya MN, Tane P, Titanji VP
Reference: 
Malaria Journal 2011, 10:167 (17 June 2011)

These findings justify the use of H. lanceolatum stem bark as anti-malarial by traditional healers of Western Cameroon, and could constitute a good basis for further studies towards development of new drug candidates or phytomedicines for malaria.

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Open Access | Quantum dots: a new tool for anti-malarial drug assays

May 11, 2011 - 12:22 -- Patrick Sampao
Author(s): 
Min-Je Ku, Fernando M Dossin, Youngseon Choi, Carolina B Moraes, Jiyoung Ryu, Rita Song, Lucio H Freitas-Junior
Reference: 
Malaria Journal 2011, 10:118 (9 May 2011)

This new assay can offer a rapid and robust platform to screen novel classes of anti-malarial drugs.

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Open Access | In vitro and in vivo assessment of the anti-malarial activity of Caesalpinia pluviosa and analysis of its active fractions

May 5, 2011 - 08:23 -- Kabogo Ndegwa
Author(s): 
Ana Carolina AV Kayano, Stefanie CP Lopes, Fernanda G Bueno, Elaine C Cabral, Wanessa CS Neiras, Lucy M Yamauchi, Mary A Foglio, Marcos N Eberlin, Joao Carlos P Mello, Fabio T Costa
Reference: 
Malaria Journal 2011, 10:112 (2 May 2011)

The findings show that the F4 fraction of C. pluviosa exhibits anti-malarial activity in vitro at non-toxic concentrations, which was potentiated in the presence of artesunate.

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Review: The State of the Art in Anti-Malarial Drug Discovery and Development

April 19, 2011 - 14:52 -- Patrick Sampao
Author(s): 
N. Burrows, Jeremy; Chibale, Kelly; N.C. Wells, Timothy
Reference: 
Current Topics in Medicinal Chemistry, Volume 11, Number 10, May 2011 , pp. 1226-1254(29)

This review summarises the antimalarials developed and registered thus far, as well as describing some of the new small molecule therapy approaches being developed as a contribution towards the malaria eradication agenda.

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Open Access | A phase I trial to evaluate the safety and pharmacokinetics of low-dose methotrexate as an anti-malarial drug in Kenyan adult healthy volunteers

March 21, 2011 - 07:29 -- Patrick Sampao
Author(s): 
Roma Chilengi., Rashid Juma., Alexis Nzila., et al.
Reference: 
Malaria Journal 2011, 10:63

Twenty five healthy adult volunteers were recruited and admitted to receive a 5 mg dose of methotrexate/day/5 days. Pharmacokinetics blood sampling was carried out at 2, 4, 6, 12 and 24 hours following each dose.

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Open Access | Anti-malarial activity of Holarrhena antidysenterica and Viola canescens, plants traditionally used against malaria in the Garhwal region of north-west Himalaya

February 9, 2011 - 07:00 -- Kabogo Ndegwa
Author(s): 
Verma G, Dua VK, Agarwal D, Atul PK
Reference: 
Malaria Journal 2011, 10:20 (2 February 2011)

The present investigation reflects the use of these traditional medicinal plants against malaria and these plants may work as potential source in the development of variety of herbal formulations for the treatment of malaria.

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Anti-malarial herbal remedies of northeast India, Assam: An ethnobotanical survey

January 18, 2011 - 07:49 -- Patrick Sampao
Author(s): 
Nima D. Namsa, M. Mandal, S. Tangjang
Reference: 
Journal of Ethnopharmacology, Volume 133, Issue 2, 27 January 2011, Pages 565-572

This study was conducted to document indigenous knowledge, usage customs and practices of medicinal plant species traditionally used by the residents of Sonitpur district of Tezpur, Assam to treat malaria and its associated symptoms.

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Schistosoma haematobium infection affects Plasmodium falciparum-specific IgG responses associated with protection against malaria

January 18, 2011 - 06:42 -- Kabogo Ndegwa
Author(s): 
D. Courtin, A. Djilali-Saiah, J. Milet, V. Soulard, O. Gaye, F. Migot-Nabias, R. Sauerwein, A. Garcia, A.J.F. Luty
Reference: 
Parasite Immunology, Volume 33, Issue 2, pages 124–131, February 2011

We have previously shown that antibody responses directed to Plasmodium falciparum merozoite surface protein (MSP)-1, MSP-2 and glutamate-rich protein (GLURP) are associated with anti-malarial protection in residents of the Niakhar area of Senegal.

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Open Access | Increased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya

November 26, 2010 - 10:15 -- Kabogo Ndegwa
Author(s): 
Spalding MD, Eyase FL, Akala HM, Bedno SA, Prigge ST, Coldren RL, Moss WJ, Waters NC
Reference: 
Malaria Journal 2010, 9:338 (24 November 2010)

During the period in which SP was the first-line anti-malarial in Kenya, highly SP-resistant parasites emerged, including isolates harboring pfdhps mutations not previously observed there.

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Ethnopharmacological communication: Ethnobotanical study on some Malaysian anti-malarial plants: A community based survey

October 15, 2010 - 14:34 -- Patrick Sampao
Author(s): 
Abdulelah H. Al-Adhroey, Zurainee M. Nor, Hesham M. Al-Mekhlafi, Rohela Mahmud
Reference: 
Journal of Ethnopharmacology, Volume 132, Issue 1, 28 October 2010, Pages 362-364

Findings of this study can be used as an ethnopharmacological basis for selecting plants for further anti-malarial phytochemical and pharmaceutical studies.

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