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anti-malarial

Not Open Access | Synthesis, characterization of chitosan–tripolyphosphate conjugated chloroquine nanoparticle and its in vivo anti-malarial efficacy against rodent parasite: A dose and duration dependent approach

July 18, 2012 - 14:32 -- Patrick Sampao
Author(s): 
Satyajit Tripathy, Sabyasachi Das, Subhankari Prasad Chakraborty, Sumanta Kumar Sahu, Panchanan Pramanik, Somenath Roy
Reference: 
International Journal of Pharmaceutics, Volume 434, Issues 1–2, 15 September 2012, Pages 292-305

In the study, the interaction of CS and TPP and the presence of chloroquine at the surface of chitosan–TPP NPs have been investigated by means of different methods like FTIR, DLS, and zeta potential.

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Not Open Access | New targets, new hope: novel drug targets for curbing malaria

June 27, 2012 - 14:32 -- Patrick Sampao
Author(s): 
Arora N, Banerjee AK
Reference: 
Mini Rev Med Chem. 2012 Mar;12(3):210-26

MalariaWorldThis review discusses potential drug targets in the malarial parasite for designing intervention strategies and suitable chemotherapeutic agents.

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Open Access | Polysaccharides from the Chinese medicinal herb Achyranthes bidentata enhance anti-malarial immunity during Plasmodium yoelii 17XL infection in mice

February 28, 2012 - 12:49 -- Patrick Sampao
Author(s): 
Zhu X, Pan Y, Zheng L, Cui L, Cao Y
Reference: 
Malaria Journal 2012, 11:49 (20 February 2012)

MalariaWorldThe aim of this study is to use the rodent malaria model Plasmodium yoelii 17XL (P. y17XL) to examine whether pretreatment with ABPS will modulate host immunity against malaria infection and improve the outcome of the disease.

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Open Access | Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii

February 28, 2012 - 11:16 -- Patrick Sampao
Author(s): 
Mout R, Xu Z, Wolf AK, Davisson VJ, Jarori GK
Reference: 
Malaria Journal 2012, 11:54 (23 February 2012)

MalariaWorldTo further evaluate the consequences of this pharmacodyamic feature, the anti-malarial activity of GA analogs with enhanced drug properties in a Plasmodium-infected animal model have been evaluated for their capacity to induce clearance of the parasite.

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Development and Optimization of a Novel 384-Well Anti-Malarial Imaging Assay Validated for High-Throughput Screening

January 11, 2012 - 08:35 -- Patrick Sampao
Author(s): 
Sandra Duffy and Vicky M. Avery
Reference: 
Am J Trop Med Hyg 2012 86:84-92

MalariaWorldWe have developed a 384-well, high-throughput imaging assay for the detection of new anti-malarial compounds, which was initially validated by screening a marine natural product library, and subsequently used to screen more than 3 million data points from a variety of compound sources.

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Effects of the anti-malarial compound cryptolepine and its analogues in human lymphocytes and sperm in the Comet assay

October 31, 2011 - 14:37 -- Patrick Sampao
Author(s): 
Rajendran C. Gopalan, Esra Emerce, Colin W. Wright, Bensu Karahalil, Ali E. Karakaya, Diana Anderson
Reference: 
Toxicology Letters, Volume 207, Issue 3, 15 December 2011, Pages 322-325

MalariaWorldIn the context of antimalarial drug development, the data suggest that all cryptolepine compounds and in particular 2,7-dibromocryptolepine cause DNA damage and therefore may not be suitable for pre clinical development as antimalarial agents.

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Open Access | Discovery of potent, novel, non-toxic anti-malarial compounds via quantum modelling, virtual screening and in vitro experimental validation

September 28, 2011 - 07:50 -- Patrick Sampao
Author(s): 
David J Sullivan Jr, Nikola Kaludov and Martin N Martinov
Reference: 
Malaria Journal 2011, 10:274

A set of innovative algorithms is used for the fast calculation and interpretation of electron-density attributes of molecular structures at the quantum level for rapid discovery of prospective pharmaceuticals.

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Open Access | Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials

August 19, 2011 - 10:33 -- Patrick Sampao
Author(s): 
Carter N, Pamba A, Duparc S, Waitumbi JN
Reference: 
Malaria Journal 2011, 10:241 (17 August 2011)

Study participants, aged >1 year, with microscopically confirmed uncomplicated Plasmodium falciparum malaria, and haemoglobin 70 g/L or haematocrit 25%, were recruited into two clinical trials conducted in six African countries (Burkina Faso, Ghana, Kenya, Nigeria, Tanzania, Mali).

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In vitro Anti-Malarial Drug Susceptibility of Temperate Plasmodium vivax from Central China

August 4, 2011 - 13:43 -- Patrick Sampao
Author(s): 
Feng Lu,Qi Gao, Kesinee Chotivanich, Hui Xia, Jun Cao, Rachanee Udomsangpetch, Liwang Cui and Jetsumon Sattabongkot
Reference: 
Am J Trop Med Hyg 2011 vol. 85 no. 2 197-201

During 2005–2006, in vitro drug susceptibility was measured for 42 clinical P. vivax isolates by using a schizont maturation inhibition technique.

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Apical Membrane Antigen 1 as an Anti-Malarial Drug Target

August 3, 2011 - 09:02 -- Patrick Sampao
Author(s): 
A. MacRaild, Christopher; F. Anders, Robin; Foley, Michael; S. Norton, Raymond
Reference: 
Current Topics in Medicinal Chemistry, Volume 11, Number 16, August 2011 , pp. 2039-2047(9)

Here we review both the structural details and functional significance of interactions at the hydrophobic cleft of AMA1, and argue that this feature of the protein represents an excellent target for the development of drugs that would block host cell invasion by malarial parasites.

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