The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 9992 malaria professionals are enjoying the free benefits of MalariaWorld today

artemisinin (ART)

K13-propeller gene polymorphisms in Plasmodium falciparum parasite population in malaria affected countries: a systematic review of prevalence and risk factors

March 12, 2019 - 15:31 -- Open Access
Author(s): 
Moses Ocan, Dickens Akena, Sam Nsobya, Moses R. Kamya, Richard Senono, Alison Annet Kinengyere and Ekwaro Obuku
Reference: 
Malaria Journal 2019 18:60, 7 March 2019

This review identified emergence of potential ART-resistance mediating k13 mutations in the African region.

Medical Treatment: 

Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7

March 3, 2016 - 14:47 -- Open Access
Author(s): 
Hanafy M. Ismail, Victoria Barton, Stephen A. Ward, et al.
Reference: 
PNAS February 23, 2016 vol. 113 no. 8 2080-2085

The artemisinin (ART)-based antimalarials have contributed significantly to reducing global malaria deaths over the past decade, but we still do not know how they kill parasites.

Medical Treatment: 

In vitro and in vivo anti-malarial activity of plants from the Brazilian Amazon

December 29, 2015 - 15:19 -- Open Access
Tags: 
Author(s): 
Renata Lima, Luiz Rocha e Silva, Adrian Pohlit, et al.
Reference: 
Malaria Journal 2015, 14:508 (18 December 2015)

Ethnobotanical or ethnopharmacological reports describe the anti-malarial use of these plants or the antiplasmodial activity of congeneric species.

Medical Treatment: 

NOT Open Access | Stability of the Antimalarial Drug Dihydroartemisinin under Physiologically Relevant Conditions: Implications for Clinical Treatment and Pharmacokinetic and In Vitro Assays

June 17, 2015 - 13:17 -- NOT Open Access
Tags: 
Author(s): 
Silvia Parapini, Piero Olliaro, Visweswaran Navaratnam, Donatella Taramelli, and Nicoletta Basilico
Reference: 
Antimicrob. Agents Chemother. July 2015 vol. 59 no. 7 4046-4052

Artemisinins are peroxidic antimalarial drugs known to be very potent but highly chemically unstable; they degrade in the presence of ferrous iron, Fe(II)-heme, or biological reductants.

Medical Treatment: 

NOT Open Access | Plasmodium falciparum Founder Populations in Western Cambodia Have Reduced Artemisinin Sensitivity In Vitro

July 21, 2014 - 14:16 -- NOT Open Access
Author(s): 
Chanaki Amaratunga, Benoit Witkowski, Dalin Dek, Vorleak Try, Nimol Khim, Olivo Miotto, Didier Ménard, and Rick M. Fairhurst
Reference: 
Antimicrob. Agents Chemother. August 2014 vol. 58 no. 8 4935-4937

Reduced Plasmodium falciparum sensitivity to short-course artemisinin (ART) monotherapy manifests as a long parasite clearance half-life.

Medical Treatment: 

NOT Open Access | Molecular monitoring of antimalarial drug resistance among Plasmodium falciparum field isolates from Odisha, India

February 27, 2013 - 12:35 -- NOT Open Access
Author(s): 
Sasmita Kumari Das Sutar, Gunanidhi Dhangadamajhi, Shantanu Kumar Kar, Manoranjan Ranjit
Reference: 
Acta Tropica, Volume 126, Issue 1, April 2013, Pages 84–87
MalariaWorld

In the absence of definite marker for artemisinin (ART) resistance, molecular monitoring of its partner drug sulfadoxine pyrimethamine (SP) in artemisinin based combination therapy (ACTs) together with chloroquine (CQ) for which ART is negatively correlated, may predict the effectiveness of ACT.

Country: 
Medical Treatment: 
Subscribe to RSS - artemisinin (ART)