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falcipain-2

High-level expression of Falcipain-2 in Escherichia coli by codon optimization and auto-induction

April 23, 2012 - 14:07 -- Patrick Sampao
Author(s): 
Emir Salas Sarduy, Aymara Cabrera Muñoz, Sebastián Alejandro Trejo, María de los A. Chavéz Planes
Reference: 
Protein Expression and Purification, Volume 83, Issue 1, May 2012, Pages 59-69

MalariaWorldIn order to facilitate the high-throughput screening of Falcipain-2 inhibitors from natural sources, we developed an economic and highly-productive overexpression system in Escherichia coli using a codon-optimized proFalcipain-2 construct.

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Short Communication: Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain

May 17, 2010 - 09:38 -- Kabogo Ndegwa
Author(s): 
Roberta Ettari, Maria Zappalà, Nicola Micale, Tanja Schirmeister, Christoph Gelhaus, Matthias Leippe, Astrid Evers, Silvana Grasso
Reference: 
European Journal of Medicinal Chemistry, Volume 45, Issue 7, July 2010, Pages 3228-3233

This paper describes the synthesis of novel peptidomimetics bearing a protected aspartyl aldeyde warhead leading to the thioacylals 2a,b and the acylals 3a,b.

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