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High-level expression of Falcipain-2 in Escherichia coli by codon optimization and auto-induction

April 23, 2012 - 14:07 -- Patrick Sampao
Emir Salas Sarduy, Aymara Cabrera Muñoz, Sebastián Alejandro Trejo, María de los A. Chavéz Planes
Protein Expression and Purification, Volume 83, Issue 1, May 2012, Pages 59-69

MalariaWorldIn order to facilitate the high-throughput screening of Falcipain-2 inhibitors from natural sources, we developed an economic and highly-productive overexpression system in Escherichia coli using a codon-optimized proFalcipain-2 construct.

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Short Communication: Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain

May 17, 2010 - 09:38 -- Kabogo Ndegwa
Roberta Ettari, Maria Zappalà, Nicola Micale, Tanja Schirmeister, Christoph Gelhaus, Matthias Leippe, Astrid Evers, Silvana Grasso
European Journal of Medicinal Chemistry, Volume 45, Issue 7, July 2010, Pages 3228-3233

This paper describes the synthesis of novel peptidomimetics bearing a protected aspartyl aldeyde warhead leading to the thioacylals 2a,b and the acylals 3a,b.

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