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Design and preparation of aza-analogues of benzo[c]phenanthridine framework with cytotoxic and antiplasmodial activities

May 17, 2010 - 09:34 -- Kabogo Ndegwa
Ange-Désiré Yapi, Nicolas Desbois, Jean-Michel Chezal, Olivier Chavignon, Jean-Claude Teulade, Alexis Valentin, Yves Blache
European Journal of Medicinal Chemistry, Volume 45, Issue 7, July 2010, Pages 2854-2859

Benzo[c]phenanthridine alkaloids represent interesting lead for the discovery of new potential antiplasmodial and/or anticancer drugs. In this field, a novel library of aza-analogs of benzo[c]phenanthroline framework derivatives was designed and prepared.

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