The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 11150 malaria professionals are enjoying the free benefits of MalariaWorld today

Aspartyl Protease Plasmepsin II

Mechanism-Based Inhibitors of the Aspartyl Protease Plasmepsin II as Potential Antimalarial Agents

May 10, 2010 - 09:29 -- Kabogo Ndegwa
D Gupta, RS Yedidi, S Varghese, LC Kovari, PM Woster
J Med Chem May 3, 2010

Four aspartyl proteases known as plasmepsins are involved in the degradation of hemoglobin by Plasmodium falciparum, which causes a large percentage of malaria deaths. The enzyme plasmepsin II (PlmII) is the most extensively studied of these aspartyl proteases and catalyzes the initial step in the breakdown of hemoglobin by the parasite.

Medical Condition: 
Subscribe to RSS - Aspartyl Protease Plasmepsin II