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Aspartyl Protease Plasmepsin II

Mechanism-Based Inhibitors of the Aspartyl Protease Plasmepsin II as Potential Antimalarial Agents

May 10, 2010 - 09:29 -- Kabogo Ndegwa
Author(s): 
D Gupta, RS Yedidi, S Varghese, LC Kovari, PM Woster
Reference: 
J Med Chem May 3, 2010

Four aspartyl proteases known as plasmepsins are involved in the degradation of hemoglobin by Plasmodium falciparum, which causes a large percentage of malaria deaths. The enzyme plasmepsin II (PlmII) is the most extensively studied of these aspartyl proteases and catalyzes the initial step in the breakdown of hemoglobin by the parasite.

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