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antimalarial antifolate inhibition

Characterisation of the bifunctional dihydrofolate synthase–folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition

May 4, 2010 - 08:13 -- Patrick Sampao
Author(s): 
Ping Wang, Qi Wang, Yonghong Yang, James K. Coward, Alexis Nzila, Paul F.G. Sims, John E. Hyde
Reference: 
Molecular and Biochemical Parasitology, Volume 172, Issue 1, July 2010, Pages 41-51

Unusually for a eukaryote, the malaria parasite Plasmodium falciparum expresses dihydrofolate synthase (DHFS) and folylpolyglutamate synthase (FPGS) as a single bifunctional protein. The two activities contribute to the essential pathway of folate biosynthesis and modification.

Medical Condition: 
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