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antimalarial antifolate inhibition

Characterisation of the bifunctional dihydrofolate synthase–folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition

May 4, 2010 - 08:13 -- Patrick Sampao
Ping Wang, Qi Wang, Yonghong Yang, James K. Coward, Alexis Nzila, Paul F.G. Sims, John E. Hyde
Molecular and Biochemical Parasitology, Volume 172, Issue 1, July 2010, Pages 41-51

Unusually for a eukaryote, the malaria parasite Plasmodium falciparum expresses dihydrofolate synthase (DHFS) and folylpolyglutamate synthase (FPGS) as a single bifunctional protein. The two activities contribute to the essential pathway of folate biosynthesis and modification.

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