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anti malarials

Development of an agent-based model to assess the impact of substandard and falsified anti-malarials: Uganda case study

January 15, 2019 - 15:19 -- Open Access
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Author(s): 
Sachiko Ozawa, Daniel R. Evans, Colleen R. Higgins, Sarah K. Laing and Phyllis Awor
Reference: 
Malaria Journal 2019 18:5, 9 January 2019

Improving the quality of treatment is essential to combat the burden of malaria and prevent the development of drug resistance.

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Private sector drug shops frequently dispense parenteral anti-malarials in a rural region of Western Uganda

August 22, 2018 - 15:10 -- Open Access
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Author(s): 
Lawrence T. Wang, Robert Bwambale, Corinna Keeler, Raquel Reyes, Rabbison Muhindo, Michael Matte, Moses Ntaro, Edgar Mulogo, Radhika Sundararajan and Ross M. Boyce
Reference: 
Malaria Journal 2018 17:305, 22 August 2018

Drug shops are major sources of parenteral anti-malarials, which should be reserved for cases of severe malaria.

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An improved SYBR Green-1-based fluorescence method for the routine monitoring of Plasmodium falciparum resistance to anti-malarial drugs

December 2, 2015 - 17:30 -- Open Access
Author(s): 
Victor Dery, Nancy Duah, Ruth Ayanful-Torgby, Sena Matrevi, Francis Anto, Neils Quashie
Reference: 
Malaria Journal 2015, 14:481 (1 December 2015)

The authors conclude that freezing and thawing of parasite culture, followed by incubation with LBS in the dark for 3 h provided a significant improvement in fluorescence signal.

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The Effect of Dosing Regimens on the Antimalarial Efficacy of Dihydroartemisinin-Piperaquine: A Pooled Analysis of Individual Patient Data

December 10, 2013 - 07:08 -- Open Access
Author(s): 
The WorldWide Antimalarial Resistance Network (WWARN) DP. Study Group
Reference: 
PLoS Med 10(12): e100156

Background

Dihydroartemisinin-piperaquine (DP) is increasingly recommended for antimalarial treatment in many endemic countries; however, concerns have been raised over its potential under dosing in young children. We investigated the influence of different dosing schedules on DP's clinical efficacy.

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NOT Open Access | Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents

July 26, 2013 - 07:14 -- NOT Open Access
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Author(s): 
Victor Hadi, Megan Hotard, Taotao Ling, Yandira G. Salinas, Gustavo Palacios, Michele Connelly, Fatima Rivas
Reference: 
European Journal of Medicinal Chemistry, Volume 65, July 2013, Pages 376–380
MalariaWorld

Protozoal diseases such as malaria are a leading world health concern.

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Solution behavior of hematin under acidic conditions and implications for its interactions with chloroquine

May 3, 2010 - 14:58 -- Patrick Sampao
Author(s): 
Maria P. Crespo, Leann Tilley and Nectarios Klonis
Reference: 
Journal of Biological Inorganic Chemistry

The analysis reveals that aqua-ligated FP has a low propensity to self-associate and that the predominant self-associated species are homodimeric hydroxide-ligated FP and heterodimeric aqua/hydroxide-ligated FP.

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