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Cytostatic versus cytocidal profiling of quinoline drug combinations via modified fixed-ratio isobologram analysis

September 19, 2013 - 14:47 -- Open Access
Gorka AP, Jacobs LM, Roepe PD
Malaria Journal 2013, 12 :332 (18 September 2013)

Drug combination therapy is the frontline of malaria treatment.

Medical Treatment: 

Invited Review: Quinolines and structurally related heterocycles as antimalarials

June 14, 2010 - 12:53 -- Kabogo Ndegwa
Kirandeep Kaur, Meenakshi Jain, Ravi P. Reddy, Rahul Jain
European Journal of Medicinal Chemistry, Volume 45, Issue 8, August 2010, Pages 3245-3264

The quinoline scaffold is prevalent in a variety of pharmacologically active synthetic and natural compounds. The discovery of chloroquine, the most famous drug containing this scaffold resulted in control and eradication of malaria for decades. The other known antimalarial drugs from the quinoline family include: quinine, amodiaquine, piperaquine, primaquine, and mefloquine.

Solution behavior of hematin under acidic conditions and implications for its interactions with chloroquine

May 3, 2010 - 14:58 -- Patrick Sampao
Maria P. Crespo, Leann Tilley and Nectarios Klonis
Journal of Biological Inorganic Chemistry

The analysis reveals that aqua-ligated FP has a low propensity to self-associate and that the predominant self-associated species are homodimeric hydroxide-ligated FP and heterodimeric aqua/hydroxide-ligated FP.

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