The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10168 malaria professionals are enjoying the free benefits of MalariaWorld today

dihydroartemisinin

Letter: Atorvastatin as a Potential Antimalarial Drug: In Vitro Synergy in Combinational Therapy with Dihydroartemisinin

January 28, 2010 - 12:17 -- Kabogo Ndegwa
Author(s): 
Hélène Savini, Jean Baptiste Souraud, Sébastien Briolant, Eric Baret, Rémy Amalvict, Christophe Rogier, and Bruno Pradines
Reference: 
Antimicrobial Agents and Chemotherapy, February 2010, p. 966-967, Vol. 54, No. 2

No abstract available

Medical Condition: 

Open Access | Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects

December 23, 2009 - 21:47 -- Ingeborg van Schayk
Author(s): 
Beesan Tan, Himanshu Naik, In-Jin Jang, Kyung-Sang Yu, Lee E Kirsch, Chang-Sik Shin, J Carl Craft, Lawrence Fleckenstein
Reference: 
Malaria Journal 2009, 8:304 (18 December 2009)

The population pharmacokinetics of artesunate (AS) and its active metabolite dihydroartemisinin (DHA) were studied in healthy subjects receiving single- or multiple-dosing of AS orally either in combination with pyronaridine (PYR) or as a monotherapy with or without food.

Technology: 

In Vitro Activities of Piperaquine, Lumefantrine, and Dihydroartemisinin in Kenyan Plasmodium falciparum Isolates and Polymorphisms in pfcrt and pfmdr1.

November 18, 2009 - 12:47 -- Patrick Sampao
Author(s): 
Leah Mwai, Steven M. Kiara, Abdi Abdirahman, Lewa Pole, Anja Rippert, Abdi Diriye, Pete Bull, Kevin Marsh, Steffen Borrmann, and Alexis Nzila
Reference: 
Antimicrobial Agents and Chemotherapy, December 2009, p. 5069-5073, Vol. 53, No. 12, doi:10.1128/AAC.00638-09

We have analyzed the in vitro chemosensitivity profiles of 115 Kenyan isolates for chloroquine (CQ), piperaquine, lumefantrine (LM), and dihydroartemisinin in association with polymorphisms in pfcrt at codon 76 and pfmdr1 at codon 86, as well as with variations of the copy number of pfmdr1.

Medical Condition: 

Artemether Lumefantrine versus Dihydroartemisinin Piperaquine for Falciparum Malaria: A Longitudinal, Randomized Trial in Young Ugandan Children

November 16, 2009 - 14:04 -- Ingeborg van Schayk
Author(s): 
Emmanuel Arinaitwe, Taylor G. Sandison, Humphrey Wanzira, Abel Kakuru, Jaco Homsy, Julius Kalamya, Moses R. Kamya, Neil Vora, Bryan Greenhouse, Philip J. Rosenthal, Jordan Tappero, and Grant Dorsey
Reference: 
Clinical Infectious Diseases 2009; Volume 49, Number 11: Pages 1629–1637, DOI: 10.1086/647946

Artemisinin-based combination therapies are now widely recommended as first-line treatment for uncomplicated malaria. However, which therapies are optimal is a matter of debate. We aimed to compare the short- and longer-term efficacy of 2 leading therapies in a cohort of young Ugandan children.

Person: 
Country: 
Medical Condition: 

Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers

November 13, 2009 - 10:58 -- Ingeborg van Schayk
Tags: 
Author(s): 
Desmond Slade, Ahmed M. Galal, Waseem Gul, Mohamed M. Radwan, Safwat A. Ahmed, Shabana I. Khan, Babu L. Tekwani, Melissa R. Jacob, Samir A. Ross, Mahmoud A. ElSohly
Reference: 
Bioorganic & Medicinal Chemistry, Volume 17, Issue 23, 1 December 2009, Pages 7949-7957

Nine dihydroartemisinin acetal dimers (6–14) with diversely functionalized linker units were synthesized and tested for in vitro antiprotozoal, anticancer and antimicrobial activity.

Medical Treatment: 

Review: Embryotoxicity of the artemisinin antimalarials and potential consequences for use in women in the first trimester

October 25, 2009 - 16:56 -- Bart G.J. Knols
Author(s): 
Robert L. Clark
Reference: 
Reproductive Toxicology, Volume 28, Issue 3, November 2009, Pages 285-296, doi:10.1016/j.reprotox.2009.05.002

Single oral doses of artesunate, dihydroartemisinin, arteether and artemether administered to rats during a sensitive period of organogenesis caused embryo deaths and malformations (malformed long bones and ventricular septal defects). Extended oral dosing (12 days or more) of monkeys once daily with 12 mg/kg-d artesunate also caused embryo deaths. The initial embryotoxic effect in both species was to kill primitive erythroblasts which are present in the embryo for a few days of gestation in rats and several weeks in primates.

 

Technology: 
Medical Condition: 

Pages

Subscribe to RSS - dihydroartemisinin