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Asymmetrical dimethylarginine (ADMA)

Open Access | Increased Asymmetric Dimethylarginine in Severe Falciparum Malaria: Association with Impaired Nitric Oxide Bioavailability and Fatal Outcome

April 27, 2010 - 13:44 -- Kabogo Ndegwa
Tsin W. Yeo, Daniel A. Lampah, Nicholas M. Anstey,. et al
PLoS Pathog 6(4): e1000868

Asymmetrical dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), is a predictor of mortality in critical illness. Severe malaria (SM) is associated with decreased NO bioavailability, but the contribution of ADMA to the pathogenesis of impaired NO bioavailability and adverse outcomes in malaria is unknown.

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