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US PMI and PATH should revise 30 million $ contract and include leading African malaria institutions as full partners (see: https://www.nature.com/articles/s41591-021-01307-8)

Yes

95%

Total votes: 58

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coartem

Novartis Malaria Initiative: best practice example of pharmaceutical industry's engagement in the fight against malaria

Author(s):

Gilbert Lefèvre, Anne Claire Marrast, Heiner Grueninger

Reference:

Annals of the New York Academy of Sciences Volume 1222, Pharmaceutical Science to Improve the Human Condition: Prix Galien 2010 pages 19–29, March 2011

Despite considerable advances in the treatment and prevention of malaria, Plasmodium falciparum is still a threat to millions of people across the world, particularly in sub-Saharan Africa, with infants and young children bearing the greatest burden in terms of morbidity and mortality.

Medical Condition:

malaria

Plasmodium falciparum

Medical Treatment:

coartem

artemether-lumefantrine

Clinical Microbiology: Efficacy and tolerability of artesunate-amodiaquine (Camoquin plus®) versus artemether-lumefantrine (Coartem®) against uncomplicated Plasmodium falciparum malaria: multisite trial in Senegal and Ivory Coast

Author(s):

Babacar Faye, André Touré Offianan, Jean Louis Ndiaye, Roger Clement Tine, Walatchin Touré, Kali Djoman, Khadime Sylla, Paulette Suzanne Ndiaye, Louis Penali, Oumar Gaye

Reference:

Tropical Medicine & International Health, Volume 15, Issue 5, May 2010, Pages: 608-613

This study demonstrates the efficacy and tolerability of AS + AQ for uncomplicated Plasmodium falciparum malaria treatment in African patients over the age of 7 years.

Country:

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Treatment with Coartem (Artemether-Lumefantrine) in Papua New Guinea

Author(s):

Sonja Schoepflin, Enmoore Lin, Benson Kiniboro, Jeana T. DaRe, Rajeev K. Mehlotra, Peter A. Zimmerman, Ivo Mueller, AND Ingrid Felger

Reference:

American Journal of Tropical Medicine Hygiene, Vol 82 : 4, 2010, pp. 529-534

After excluding genetic host factors by genotyping potentially relevant cytochrome P450 loci, the high number of treatment failures in our study is best explained by poor adherence to complex dosing regimens in combination with insufficient fat supplementation, which are both crucial parameters for the outcome of Coartem treatment.

Country:

Papua New Guinea

Medical Condition:

malaria

Medical Treatment:

coartem

Arthemeter-Lumefantrine

Review: Impact of the large-scale deployment of artemether/lumefantrine on the malaria disease burden in Africa: case studies of South Africa, Zambia and Ethiopia

Author(s):

Karen I Barnes, Pascalina Chanda, Gebre Ab Barnabas

Reference:

Malaria Journal 2009, 8(Suppl 1):S8 (12 October 2009)

Malaria can be controlled in endemic countries by using artemisinin-based combination therapy (ACT) in combination with indoor residual spraying (IRS) and insecticide-treated nets (ITNs). At least 40 malaria-endemic countries in sub-Saharan Africa now recommend the use of ACT as first-line treatment for uncomplicated falciparum malaria as a cornerstone of their malaria case management.

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Review: Dispersible formulation of artemether/lumefantrine: specifically developed for infants and young children

Author(s):

Salim Abdulla, Issaka Sagara

Reference:

Malaria Journal 2009, 8(Suppl 1):S7 (12 October 2009)

Ahead of a call from WHO for child-friendly medicines, Novartis, working in partnership with Medicines for Malaria Venture (MMV), started the development of a new formulation of AL for infants and young children: Coartem® Dispersible.

Medical Condition:

Medical Treatment:

Review: Safety profile of Coartem®: the evidence base

Author(s):

Catherine Falade, Christine Manyando

Reference:

Malaria Journal 2009, 8(Suppl 1):S6 (12 October 2009)

This article reviews the comprehensive data on the safety and tolerability from over 6,300 patients who have taken artemether/lumefantrine (Coartem®) as part of Novartis-sponsored or independently-sponsored clinical trials.

Medical Condition:

Medical Treatment:

Review: The clinical efficacy of artemether/lumefantrine (Coartem®)

Author(s):

Michael Makanga, Srivicha Krudsood

Reference:

Malaria Journal 2009, 8(Suppl 1):S5 (12 October 2009)

Current World Health Organization (WHO) guidelines for the treatment of uncomplicated falciparum malaria recommend the use of artemisinin-based combination therapy (ACT). Artemether/lumefantrine is an ACT prequalified by the WHO for efficacy, safety and quality, approved by Swissmedic in December 2008 and recently approved by the USA FDA. Coartem® is a fixed-dose combination of artemether and lumefantrine.

Medical Condition:

Medical Treatment:

Review: Understanding the pharmacokinetics of Coartem®

Tags:

malaria

Author(s):

Abdoulaye Djimdé, Gilbert Lefèvre

Reference:

Malaria Journal 2009, 8(Suppl 1):S4 (12 October 2009)

In conclusion, knowledge of the pharmacokinetic profiles of artemether and lumefantrine is increasing within a range of settings, including infants and children. However, additional data would be warranted to better characterize artemether and lumefantrine pharmacokinetics in patients with hepatic impairment, in pregnant women, and in patients undergoing HIV/AIDS chemotherapy.

Technology:

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Review: Coartem®: the journey to the clinic

Tags:

malaria

Author(s):

Zulfiqarali G Premji

Reference:

Malaria Journal 2009, 8(Suppl 1):S3 (12 October 2009)

Artemisinin, from which the artemether component of Coartem®(artemether/lumefantrine, AL) is derived, is obtained from the plant sweet wormwood (Artemisia annua) which has been used for over 2,000 years as a Chinese herbal remedy. Artemisinin was first identified by Chinese researchers as the active anti-malarial constituent of A. annua and its derivatives were found to be the most potent of all anti-malarial drugs.

Medical Treatment:

coartem

drugs

artemisia

Introduction: Malaria management - progress made and challenges still to face

Tags:

malaria

Author(s):

Bernhards R Ogutu

Reference:

Malaria Journal 2009, 8(Suppl 1):S1 (12 October 2009)

This supplement reviews the contribution made by AL as an ACT to the tremendous progress made in the control of malaria and establishes effective treatment as a cornerstone in the foundation of effective, quality patient care for infants, children and adults with malaria.

Medical Treatment:

coartem

ACT

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