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plasmodium falciparum

Nedd8 hydrolysis by UCH proteases in Plasmodium parasites

November 5, 2019 - 12:51 -- Open Access
Author(s): 
Maryia Karpiyevich, Sophie Adjalley, Marco Mol, David B. Ascher, Bethany Mason, Gerbrand J. van der Heden van Noort, Heike Laman, Huib Ovaa, Marcus C. S. Lee, Katerina Artavanis-Tsakonas
Reference: 
PLoS Pathog 15(10): e1008086.

Plasmodium parasites are the causative agents of malaria, a disease with wide public health repercussions. Increasing drug resistance and the absence of a vaccine make finding new chemotherapeutic strategies imperative.

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ABO Blood Groups Influence Macrophage-mediated Phagocytosis of Plasmodium falciparum-infected Erythrocytes

November 11, 2012 - 09:51 -- Open Access
Author(s): 
Kayla T. Wolofsky, Kodjo Ayi, Donald R. Branch, Annika K. Hult, Martin L. Olsson, W. Conrad Liles, Christine M. Cserti-Gazdewich, Kevin C. Kain
Reference: 
PLoS Pathog 8(10): e1002942
MalariaWorld

Erythrocyte polymorphisms associated with a survival advantage to Plasmodium falciparum infection have undergone positive selection.

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Structural Basis for the ABO Blood-Group Dependence of Plasmodium falciparum Rosetting

July 18, 2012 - 14:41 -- Kabogo Ndegwa
Author(s): 
Inès Vigan-Womas, Micheline Guillotte, Alexandre Juillerat, Audrey Hessel, Bertrand Raynal, Patrick England, Jacques H. Cohen, Olivier Bertrand, Thierry Peyrard, Graham A. Bentley, Anita Lewit-Bentley, Odile Mercereau-Puijalon
Reference: 
PLoS Pathog 8(7): e1002781

The ABO blood group influences susceptibility to severe Plasmodium falciparum malaria.

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Open Access | NSR-seq transcriptional profiling enables identification of a gene signature of Plasmodium falciparum parasites infecting children

February 22, 2011 - 07:38 -- Kabogo Ndegwa
Author(s): 
M Vignali, CD Armour, J Chen, R Morrison, JC Castle, MC Biery, H Bouzek, W Moon, T Babak, M Fried, CK Raymond, PE Duffy
Reference: 
Journal of Clinical Investigation

Malaria caused by Plasmodium falciparum results in approximately 1 million annual deaths worldwide, with young children and pregnant mothers at highest risk.

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Open Access | Addendum: Functional characteristics of the malaria parasite's "chloroquine resistance transporter": Implications for chemotherapy

January 3, 2011 - 08:53 -- Kabogo Ndegwa
Author(s): 
Martin RE, Marchetti RV, Cowan AI, Howitt SM, Bröer S, Kirk K
Reference: 
Virulence, Volume 1, Issue 4 July/August 2010, Pages 304 – 308

Chloroquine (CQ) was the best and most heavily used drug in the fight against malaria.

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Open Access | External quality assessment on the use of malaria rapid diagnostic tests in a non-endemic setting

December 16, 2010 - 08:00 -- Kabogo Ndegwa
Author(s): 
Gillet P, Mukadi P, Vernelen K, Van Esbroeck M, Muyembe J, Bruggeman C, Jacobs J
Reference: 
Malaria Journal 2010, 9:359 (13 December 2010)

In this non-endemic setting, errors in RDT performance were mainly related to RDT test line interpretations, partly due to incorrect package insert instructions.

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