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Short Communication: Implication of intracellular glutathione and its related enzymes on resistance of malaria parasites to the antimalarial drug arteether

January 21, 2011 - 08:42 -- Patrick Sampao
Ramesh Chandra, L.M. Tripathi, J.K. Saxena, S.K. Puri
Parasitology International, Volume 60, Issue 1, January 2011, Pages 97-100

In this study, we examined the relationship between the intracellular levels of glutathione (GSH) and antioxidant enzymes and resistance to the artemisinin-based drug arteether in experimentally selected arteether-resistant Plasmodium vinckei.

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Review: Embryotoxicity of the artemisinin antimalarials and potential consequences for use in women in the first trimester

October 25, 2009 - 16:56 -- Bart G.J. Knols
Robert L. Clark
Reproductive Toxicology, Volume 28, Issue 3, November 2009, Pages 285-296, doi:10.1016/j.reprotox.2009.05.002

Single oral doses of artesunate, dihydroartemisinin, arteether and artemether administered to rats during a sensitive period of organogenesis caused embryo deaths and malformations (malformed long bones and ventricular septal defects). Extended oral dosing (12 days or more) of monkeys once daily with 12 mg/kg-d artesunate also caused embryo deaths. The initial embryotoxic effect in both species was to kill primitive erythroblasts which are present in the embryo for a few days of gestation in rats and several weeks in primates.


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