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artesunate

Case Report: Combined Intravenous Treatment with Artesunate and Quinine for Severe Malaria in Italy

August 6, 2010 - 07:32 -- Patrick Sampao
Author(s): 
Alessandro B., Lina T., et al.
Reference: 
Am J Trop Med Hyg, Aug 2010; 83: 274 - 276.

We report a series of eight imported severe falciparum malaria cases treated with IVA combined with intravenous quinine (IVQ). This combined therapy was found to be efficacious, safe, and well-tolerated.

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Fixed artesunate–amodiaquine combined pre-formulation study for the treatment of malaria

July 9, 2010 - 07:00 -- Patrick Sampao
Author(s): 
Tina K., Fawaz F., et al.
Reference: 
International Journal of Pharmaceutics, Volume 395, Issues 1-2, 16 August 2010, Pages 198-204

This paper reports the initial research phase of the pre-development process of an AS–AQ formulation, further developed by the Drug for Neglected Diseases Initiative (DNDi).

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Open Access | Monitoring for Plasmodium falciparum drug resistance to artemisinin and artesunate in Binh Phuoc Province, Vietnam: 1998-2009

June 25, 2010 - 09:58 -- Kabogo Ndegwa
Author(s): 
Thanh NV, Toan TQ, Cowman AF, Casey GJ, Phuc BQ, Tien NT, Hung NM, Biggs B
Reference: 
Malaria Journal 2010, 9:181 (24 June 2010)

This study showed stable levels of P. falciparum sensitivity to artemisinin compounds in the two sites over a ten-year period.

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Tolerability and efficacy of a pediatric granule formulation of artesunate-mefloquine in young children from cameroon with uncomplicated falciparum malaria

June 9, 2010 - 08:06 -- Kabogo Ndegwa
Author(s): 
F Tietche, D Chelo, NK Mina Ntoto, FM Djoukoue, C Hatz, S Frey, A Frentzel, S Trapp, R Zielonka, EA Mueller
Reference: 
Am. J. Trop. Med. Hyg., 82(6), 2010, pp. 1034-1040

A fixed-dose pediatric formulation of artesunate and mefloquine (Artequin Pediatric) has been developed. In this open, non-comparative study in Cameroonian children with uncomplicated falciparum malaria, the safety and efficacy of this formulation was tested, with a particular emphasis on the risk of neuropsychiatric adverse events (AEs). In total, 220 subjects, weighing between 10 and 20 kg, were enrolled; 213 qualified for analysis.

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Open Access | Reliability of Antimalarial Sensitivity Tests Depends on Drug Mechanisms of Action

May 6, 2010 - 07:23 -- Patrick Sampao
Author(s): 
Sharon Wein, Marjorie Maynadier, Christophe Tran Van Ba, Rachel Cerdan, Suzanne Peyrottes, Laurent Fraisse, and Henri Vial
Reference: 
J. Clin. Microbiol., May 2010; 48: 1651 - 1660.

Our results suggest some minimal conditions to apply these tests that should give rise to a standard 50% inhibitory concentration, regardless of the mechanism of action of the compounds, and highlight that the most commonly used in vitro antimalarial activity tests do not have the same potential.

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Five Years of Large-Scale dhfr and dhps Mutation Surveillance Following the Phased Implementation of Artesunate Plus Sulfadoxine-Pyrimethamine in Maputo Province, Southern Mozambique

May 4, 2010 - 14:10 -- Patrick Sampao
Author(s): 
Jaishree Raman, Francesca Little, Cally Roper, Immo Kleinschmidt, Yasmin Cassam, Rajendra Maharaj, and Karen I. Barnes
Reference: 
Am J Trop Med Hyg, May 2010; 82: 788 - 794.

The high "quintuple" mutation prevalence suggests a limited useful therapeutic lifespan of AS-SP for treating uncomplicated malaria, and may curb efficacy of SP-monotherapy for intermittent preventive treatment in Mozambique.

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Open Access | Research: Randomized controlled trial of artesunate or artemether in Vietnamese adults with severe falciparum malaria

April 16, 2010 - 08:29 -- Kabogo Ndegwa
Author(s): 
Phu NH, Tuan PQ, Day N, Mai NT, Chau TT, Chuong LV, Sinh DX, White NJ, Farrar J, Tran HT
Reference: 
Malaria Journal 2010, 9:97 (15 April 2010)

Both artemether and artesunate have been shown to be superior to quinine for the treatment of severe falciparum malaria in Southeast Asian adults, although the magnitude of the superiority has been greater for artesunate than artemether. These two artemisinin derivatives had not been compared in a randomized trial.

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Open Access | Research: Oral Activated Charcoal Prevents Experimental Cerebral Malaria in Mice and in a Randomized Controlled Clinical Trial in Man Did Not Interfere with the Pharmacokinetics of Parenteral Artesunate

April 16, 2010 - 08:07 -- Kabogo Ndegwa
Author(s): 
J. Brian de Souza, Uduak Okomo,Michael Walther, et al.
Reference: 
PLoS ONE 5(4): e9867

If future studies succeed in establishing the efficacy of oAC in human malaria, then the characteristics of being inexpensive, well-tolerated at high doses and requiring no sophisticated storage would make oAC a relevant candidate for adjunct therapy to reduce mortality from severe malaria, or for immediate treatment of suspected severe malaria in a rural setting.

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Design of a fixed-dose paediatric combination of artesunate and amodiaquine hydrochloride

March 5, 2010 - 11:14 -- Kabogo Ndegwa
Author(s): 
C. Okwelogu, B. Clark, M. de Matas, D. Ifudu, C. Igwilo, B. Silva, P. York
Reference: 
International Journal of Pharmaceutics, Volume 387, Issues 1-2, 15 March 2010, Pages 19-25

It was therefore concluded that a stable, versatile paediatric preparation of the two drugs could be prepared by blending pre-formulated granules containing the individual constituents rather than producing a combined granule comprising intimate mixtures of the two agents.

Plasmodium falciparum: In vitro interaction of quassin and neo-quassin with artesunate, a hemisuccinate derivative of artemisinin

February 19, 2010 - 12:36 -- Kabogo Ndegwa
Author(s): 
Kirti Mishra, Dipjyoti Chakraborty, Amita Pal, Nrisingha Dey
Reference: 
Experimental Parasitology, Volume 124, Issue 4, April 2010, Pages 421-427

Quassia amara L. (Family Simaroubaceae) is known to have several medicinal properties including the activity against malaria. An HPLC method was employed for purification of the biologically active quassinoids; quassin (Q) and neo-quassin (NQ), further characterized by MALDI-TOF analyses.

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