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artesunate

Repeated Artemisinin-Based Combination Therapies in a Malaria Hyperendemic Area of Mali: Efficacy, Safety, and Public Health Impact

July 4, 2012 - 12:36 -- Patrick Sampao
Author(s): 
Issaka Sagara, Bakary Fofana, Abdoulaye A. Djimde, et al.
Reference: 
Am J Trop Med Hyg 2012 87:50-56

MalariaWorldWe conducted a randomized trial comparing artemether-lumefantrine, artesunate plus amodiaquine (AS+AQ) and artesunate plus sulfadoxine-pyrimethamine (AS+SP) in patients 6 months of age and older with uncomplicated malaria in Mali from July 2005 to July 2007.

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NOT Open Access | Artesunate versus quinine for treating severe malaria.

June 20, 2012 - 14:57 -- Patrick Sampao
Author(s): 
Sinclair D, Donegan S, Isba R, Lalloo DG.
Reference: 
Cochrane Database Syst Rev. 2012 Jun 13;6

MalariaWorldThis review examines whether treatment with artesunate, instead of the standard treatment quinine, would result in fewer deaths and better treatment outcomes.

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Post-treatment haemolysis in severe imported malaria after intravenous artesunate: case report of three patients with hyperparasitaemia

May 23, 2012 - 10:16 -- Kabogo Ndegwa
Author(s): 
Rolling T, Schmiedel S, Wichmann D, Wittkopf D, Burchard G, Cramer JP
Reference: 
Malaria Journal 2012, 11:169 (17 May 2012)

MalariaWorldParenteral artesunate has been shown to be a superior treatment option compared to parenteral quinine in adults and children with severe malaria.

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Open Access | Capillary electrophoresis for the assay of fixed-dose combination tablets of artesunate and amodiaquine

May 8, 2012 - 14:10 -- Kabogo Ndegwa
Author(s): 
Amin N, Blanchin M, Aké M, Montels J, Fabre H
Reference: 
Malaria Journal 2012, 11:149 (3 May 2012)

MalariaWorldThe MEKC method proposed is reliable for the determination of artesunate and amodiaquine hydrochloride in fixed-dose combination tablets.

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Open Access | Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults

May 2, 2012 - 14:29 -- Kabogo Ndegwa
Author(s): 
Byakika-Kibwika P, Lamorde M, Mayito J, Nabukeera L, Mayanja-Kizza H, Katabira E, Hanpithakpong W, Obua C, Pakker N, Lindegardh N, Tarning J, de Vries PJ, Merry C
Reference: 
Malaria Journal 2012, 11:132 (27 April 2012)

MalariaWorldPlasma concentrations of artesunate and dihydroartemisinin were achieved rapidly with rapid and complete symptom resolution and parasite clearance with no adverse events.

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Open Access | Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections

May 2, 2012 - 14:27 -- Kabogo Ndegwa
Author(s): 
Pillai DR, Lau R, Khairnar K, Lepore R, Via A, Staines HM, Krishna S
Reference: 
Malaria Journal 2012, 11:131 (27 April 2012)

MalariaWorldThese findings were further explored in molecular modelling experiments that suggest mutations in pfatp6 are unlikely to affect differential binding of artemisinins at their proposed site, whereas there may be differences in such binding associated with mutations in pfmdr1.

Open Access | 0906 A new clinical variant of the post-malaria neurological syndrome

February 9, 2012 - 12:58 -- Patrick Sampao
Author(s): 
A Pace, S Edwards
Reference: 
J Neurol Neurosurg Psychiatry 2012;83

MalariaWorldWe report a case of brainstem and spinal cord inflammation without supratentorial involvement following recovery from Plasmodium falciparum infection.

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A Simple Dose Regimen of Artesunate and Amodiaquine Based on Arm Span- or Age Range for Childhood Falciparum Malaria: A Preliminary Evaluation

November 8, 2011 - 08:23 -- Kabogo Ndegwa
Author(s): 
Akintunde Sowunmi, Ibukun A. Akinrinola, Grace O. Gbotosho, Titilope M. Okuboyejo, and Christian T. Happi
Reference: 
J Trop Pediatr (2011)

MalariaWorldA dose regimen of artesunate and amodiaquine based on arm span- or age range (DRAAAS), derived from a study of 1674 children, was compared with standard dose regimen of the same drugs calculated according to body weight (SDRAA) in 68 malarious children.

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Efficacy and Effectiveness of Mefloquine and Artesunate Combination Therapy for Uncomplicated Plasmodium falciparum Malaria in the Peruvian Amazon

September 8, 2011 - 07:53 -- Patrick Sampao
Author(s): 
Alexandre Macedo de Oliveira, Jorge Chavez, Gabriel Ponce de Leon, Salomon Durand, Nancy Arrospide, Jacquelin Roberts, Cesar Cabezas and Wilmer Marquiño
Reference: 
Am J Trop Med Hyg 2011 vol. 85 no. 3 573-578

Our study shows that MQ + AS is highly efficacious in the Peruvian Amazon.

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Open Access | Treatment of imported severe malaria with artesunate instead of quinine - more evidence needed?

September 8, 2011 - 07:48 -- Kabogo Ndegwa
Author(s): 
Cramer JP, Lopez-Velez R, Burchard GD, Grobusch MP and de Vries PJ
Reference: 
Malaria Journal 2011, 10:256 (7 September 2011)

Rapid and fast acting anti-malarials are essential to treat severe malaria.

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