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artesunate

Safety of a fixed-dose combination of artesunate and amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in real-life conditions of use in Côte d’Ivoire

January 4, 2017 - 17:52 -- Open Access
Author(s): 
Serge-Brice Assi, Yapo Thomas Aba, Mea Antoine Tanoh, et al.
Reference: 
Malaria Journal 2017 16:8, 3 January 2017

The fixed dose artesunate–amodiaquine combination ASAQ Winthrop® for the unsupervised treatment of uncomplicated falciparum malaria under real-life conditions of care in Côte d’Ivoire is well tolerated.

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The role of red blood cell exchange for severe imported malaria in the artesunate era: a retrospective cohort study in a referral centre

April 15, 2016 - 15:19 -- Open Access
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Author(s): 
Antonia Calvo-Cano, Joan Gómez-Junyent, Miguel Lozano, Pedro Castro, Joan Cid, Jose María Nicolás, Llorenç Quintó, Maite Martin, Jose Muñoz and Joaquim Gascon
Reference: 
Malaria Journal 2016 15:216, 14 April 2016

In this study RBC exchange failed to show benefits in terms of parasite clearance probably due to the small number of patients analysed.

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Efficacy of intranasal administration of artesunate in experimental cerebral malaria

December 22, 2014 - 10:44 -- Open Access
Author(s): 
Marijon A, Bonnot G, Fourier A, Bringer C, Lavoignat A, Gagnieu M, Bienvenu A, Picot S
Reference: 
Malaria Journal 2014, 13 :501 (16 December 2014)

Intranasal delivery is an efficient route to timely and efficiently administer artesunate and therefore may contribute to decreasing malaria-related mortality.

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Not Open Access | Intravenous β-artemether formulation (ARM NLC) as a superior alternative to commercial artesunate formulation

October 12, 2012 - 16:48 -- Patrick Sampao
Author(s): 
Sushant Patil, Medha Joshi, Sulabha Pathak, Shobhona Sharma and Vandana Patravale
Reference: 
Journal of Antimicrobial Chemotherapy, Volume 67, Issue 11 Pp. 2713-2716

MalariaWorldThe study compared the in vivo pharmacodynamic efficacy of ARM NLC with C-AST in a murine model. For this study, the Peters 4 day suppressive test was adopted. Plasmodium berghei was the causative organism for inducing malaria in mice.

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Case Report: Artesunate for Severe Acute Plasmodium falciparum Infection in a Patient with Myasthenia Gravis

September 7, 2012 - 04:34 -- Patrick Sampao
Author(s): 
Nathalie Dournon, Pierre Buffet, Eric Caumes, Bernard Clair and Stéphane Jauréguiberry
Reference: 
Am J Trop Med Hyg 2012 87:435-436

MalariaWorldWe report a case of severe malaria in a patient with underlying myasthenia gravis who was successfully treated with artesunate.

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A Longitudinal Trial Comparing Chloroquine as Monotherapy or in Combination with Artesunate, Azithromycin or Atovaquone-Proguanil to Treat Malaria

August 31, 2012 - 14:37 -- Patrick Sampao
Author(s): 
Miriam K. Laufer, Phillip C. Thesing, Fraction K. Dzinjalamala, Osward M. Nyirenda, Rhoda Masonga, Matthew B. Laurens, Abbie Stokes-Riner, Terrie E. Taylor, Christopher V. Plowe
Reference: 
PLoS ONE 7(8): e42284.

MalariaWorldWe aimed to compare the ability of different partner drugs to preserve chloroquine efficacy and prevent the re-emergence of resistance.

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Parasite-based malaria diagnosis: Are Health Systems in Uganda equipped enough to implement the policy?

August 27, 2012 - 14:15 -- Patrick Sampao
Author(s): 
Kyabayinze DJ, Achan J, Nakanjako D, Mpeka B, Mawejje H, Mugizi R, Kalyango JN, D'Alessandro U, Talisuna AO, Van Geertruden J
Reference: 
BMC Public Health 2012, 12:695 (24 August 2012)

MalariaWorldThis study assessed the health systems capacity to absorb PMD at primary health care facilities in Uganda.

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NOT Open Access | A Simple Dose Regimen of Artesunate and Amodiaquine Based on Arm Span- or Age Range for Childhood Falciparum Malaria: A Preliminary Evaluation

August 7, 2012 - 11:42 -- Kabogo Ndegwa
Author(s): 
Akintunde Sowunmi, Ibukun A. Akinrinola, Grace O. Gbotosho, Titilope M. Okuboyejo, and Christian T. Happi
Reference: 
J Trop Pediatr (2012) 58 (4): 263-268

MalariaWorldA dose regimen of artesunate and amodiaquine based on arm span- or age range (DRAAAS), derived from a study of 1674 children, was compared with standard dose regimen of the same drugs calculated according to body weight (SDRAA) in 68 malarious children.

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Pharmacokinetic profiles of artesunate following multiple intravenous doses of 2, 4, and 8 mg/kg in healthy volunteers: Phase 1b study

August 3, 2012 - 07:00 -- Kabogo Ndegwa
Author(s): 
Miller R, Li Q, Cantilena LR, Leary KJ, Saviolakis GA, Melendez V, Smith B, Weina PJ
Reference: 
Malaria Journal 2012, 11:255 (1 August 2012)

MalariaWorldBackground

The safety of injectable AS, even at the highest dose of 8 mg/kg increases the probability of therapeutic success of the drug even in patients with large variability of parasitaemia.

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Not Open Access | Severe malaria, artesunate and haemolysis

July 18, 2012 - 15:13 -- Patrick Sampao
Author(s): 
Pietro Caramello, Rosanna Balbiano, Tiziano De Blasi, Monica Chiriotto, Maura Deagostini and Guido Calleri
Reference: 
J. Antimicrob. Chemother. (2012) 67(8): 2053-2054

We report the case of a 22-year-old Italian woman who presented to Amedeo di Savoia Hospital in Turin in September 2011, with fever, chills and headache after a 4 week stay in Sierra Leone, without taking malaria chemoprophylaxis.

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