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Treatment with Coartem (Artemether-Lumefantrine) in Papua New Guinea

April 13, 2010 - 08:58 -- Patrick Sampao
Sonja Schoepflin, Enmoore Lin, Benson Kiniboro, Jeana T. DaRe, Rajeev K. Mehlotra, Peter A. Zimmerman, Ivo Mueller, AND Ingrid Felger
American Journal of Tropical Medicine Hygiene, Vol 82 : 4, 2010, pp. 529-534

After excluding genetic host factors by genotyping potentially relevant cytochrome P450 loci, the high number of treatment failures in our study is best explained by poor adherence to complex dosing regimens in combination with insufficient fat supplementation, which are both crucial parameters for the outcome of Coartem treatment.

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