The study suggests that the contribution of IRS to malaria and mosquito control is not entirely perceived by the beneficiaries, and that other as cost effective interventions such as insecticide-treated nets are favoured over IRS.
This study assessed resistance to permethrin and DDT in seven populations of Anopheles arabiensis from Sudan.
Malaria continues to threaten the lives of people despite huge funds made available to fight this preventable disease. According to the 2010 report “Breaking the Cycle: Saving Lives and Protecting the Future” by the Department for International Development (DFID), global funding for malaria has increased from $0.733 billion in 2006 to $1.94 billion in 2009. Despite the increasing funds for malaria control, the disease still kills about 800,000 people each year with the Africa [Sub-Saharan region] being the hardest hit [90 percent].
This investigation was to explore the metabolic status of GSTs in two Indian DDT-resistant malaria vectors, Anopheles culicifacies and Anopheles annularis, and one DDT-susceptible vector, Anopheles fluviatilis. Malkangiri and Koraput districts of Orissa State, endemic for falciparum malaria and having a long insecticide spraying history, were the study areas.
The existence of high level of DDT and pyrethroid resistance with the possibility of cross-resistance to each other and other classes of agricultural pesticides could seriously jeopardise the efficacy of both ITNs and IRS in the country in the future.
Two alternative kdr-like mutations, L1014S and L1014F, were detected in An. stephensi with a high allelic frequency of L1014S.
Encouraged by the early success of using dichloro-diphenyl-trichloroethane (DDT) against malaria, the World Health Organization (WHO) embarked on the Global Malaria Eradication Program (GMEP) in 1955.
However well intentioned, Tren and Roberts (2010)—as with much of AFM’s output—do more to fuel those “interminable debates” than to meaningfully inform decisions that will save people’s lives.
In the dry season, the kdr frequency was significantly higher in Plasmodium falciparum-infected mosquitoes, indicating that mosquitoes bearing a kdr mutation have a better adult survival, hence a higher likelihood of becoming infectious.