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quinolones

Open Access | Increased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya

November 26, 2010 - 10:15 -- Kabogo Ndegwa
Author(s): 
Spalding MD, Eyase FL, Akala HM, Bedno SA, Prigge ST, Coldren RL, Moss WJ, Waters NC
Reference: 
Malaria Journal 2010, 9:338 (24 November 2010)

During the period in which SP was the first-line anti-malarial in Kenya, highly SP-resistant parasites emerged, including isolates harboring pfdhps mutations not previously observed there.

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Synthesis and structure–activity relationships of antimalarial 4-oxo-3-carboxyl quinolones

April 7, 2010 - 11:14 -- Kabogo Ndegwa
Author(s): 
Yiqun Zhang, W. Armand Guiguemde, Martina Sigal, Fangyi Zhu, Michele C. Connelly, Solomon Nwaka, R. Kiplin Guy
Reference: 
Bioorganic & Medicinal Chemistry, Volume 18, Issue 7, 1 April 2010, Pages 2756-2766

The increasing prevalence of multi-drug-resistant Plasmodium falciparum drives the ongoing need for the development of new antimalarial drugs.

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