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Mechanism of Endosomal TLR Inhibition by Antimalarial Drugs and Imidazoquinolines

April 7, 2011 - 07:15 -- Kabogo Ndegwa
Alenka Kuznik, Mojca Bencina, Urban Svajger, Matjaz Jeras, Blaz Rozman, and Roman Jerala
The Journal of Immunology April 15, 2011 vol. 186 no. 8 4794-4804

Endosomal TLRs play an important role in innate immune response as well as in autoimmune processes.

Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug

March 25, 2010 - 20:12 -- Patrick Sampao
Jacob H. Rand, Xiao-Xuan Wu, Anthony S. Quinn, Anthony W. Ashton, Pojen P. Chen, James J. Hathcock, Harry A. M. Andree, and Douglas J. Taatjes
Blood, 18 March 2010, Vol. 115, No. 11, pp. 2292-2299.

In conclusion, HCQ reversed antiphospholipid-mediated disruptions of AnxA5 on PLBs and cultured cells, and in APS patient plasmas. These results support the concept of novel therapeutic approaches that address specific APS disease mechanisms.

Medical Condition: 
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