Endosomal TLRs play an important role in innate immune response as well as in autoimmune processes.
The Journal of Immunology April 15, 2011 vol. 186 no. 8 4794-4804
Blood, 18 March 2010, Vol. 115, No. 11, pp. 2292-2299.
In conclusion, HCQ reversed antiphospholipid-mediated disruptions of AnxA5 on PLBs and cultured cells, and in APS patient plasmas. These results support the concept of novel therapeutic approaches that address specific APS disease mechanisms.