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V-type H+-ATPase

Inhibition of Plasmodium falciparum pH regulation by small molecule indole derivatives results in rapid parasite death

March 11, 2010 - 14:00 -- Patrick Sampao
Donelly A. van Schalkwyk, Xie W.A. Chan, Paola Misiano, Stefania Gagliardi, Carlo Farina, Kevin J. Saliba
Biochemical Pharmacology, Volume 79, Issue 9, 1 May 2010

The V-type H+-ATPase is critical during the intraerythrocytic stage of the human malaria parasite Plasmodium falciparum. Our data support the disruption of parasite pH regulation through inhibition of its V-type H+-ATPase as an antimalarial approach.

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