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Ormocarpum kirkii

Antiplasmodial activity of (I-3,II-3)-biflavonoids and other constituents from Ormocarpum kirkii

March 9, 2010 - 12:36 -- Ingeborg van Schayk
Author(s): 
Liene Dhooghe, Sheila Maregesi, Irena Mincheva, Daneel Ferreira, Jannie P.J. Marais, Filip Lemière, An Matheeussen, Paul Cos, Louis Maes, Arnold Vlietinck, Sandra Apers and Luc Pieters
Reference: 
Phytochemistry Article in Press, Corrected Proof

Preliminary screening of a series of medicinal plants, traditionally used in Tanzania, showed an IC50 of 15.6–31.2 μg/ml for the crude extract of the root of Ormocarpum kirkii S. Moore (Papilionaceae) against Plasmodium falciparum. A bioguided isolation was performed in order to isolate the active constituents.

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