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Ormocarpum kirkii

Antiplasmodial activity of (I-3,II-3)-biflavonoids and other constituents from Ormocarpum kirkii

March 9, 2010 - 12:36 -- Ingeborg van Schayk
Liene Dhooghe, Sheila Maregesi, Irena Mincheva, Daneel Ferreira, Jannie P.J. Marais, Filip Lemière, An Matheeussen, Paul Cos, Louis Maes, Arnold Vlietinck, Sandra Apers and Luc Pieters
Phytochemistry Article in Press, Corrected Proof

Preliminary screening of a series of medicinal plants, traditionally used in Tanzania, showed an IC50 of 15.6–31.2 μg/ml for the crude extract of the root of Ormocarpum kirkii S. Moore (Papilionaceae) against Plasmodium falciparum. A bioguided isolation was performed in order to isolate the active constituents.

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