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CYP450

Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277

March 5, 2010 - 09:10 -- Kabogo Ndegwa
Author(s): 
Lin Zhou, André Alker, Jonathan L. Vennerstrom et al.
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 18, Issue 5, 1 March 2008, Pages 1555-1558

The antimalarial synthetic ozonide OZ277 (RBx11160) was hydroxylated by human liver microsomes at the distal bridgehead carbon atoms of the spiroadamantane substructure to form two carbinol metabolites devoid of antimalarial activity.

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