The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 11151 malaria professionals are enjoying the free benefits of MalariaWorld today


Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277

March 5, 2010 - 09:10 -- Kabogo Ndegwa
Lin Zhou, André Alker, Jonathan L. Vennerstrom et al.
Bioorganic & Medicinal Chemistry Letters, Volume 18, Issue 5, 1 March 2008, Pages 1555-1558

The antimalarial synthetic ozonide OZ277 (RBx11160) was hydroxylated by human liver microsomes at the distal bridgehead carbon atoms of the spiroadamantane substructure to form two carbinol metabolites devoid of antimalarial activity.

Subscribe to RSS - ozonide