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vaccine

One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen

February 14, 2017 - 15:14 -- Open Access
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Author(s): 
Ivan Campeotto, Adi Goldenzweig, Sarel J. Fleishman, et al.
Reference: 
PNAS January 31, 2017 vol. 114 no. 5 998-1002

Many promising vaccine candidates from pathogenic viruses, bacteria, and parasites are unstable and cannot be produced cheaply for clinical use.

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Not Open Access | Assessing the economic benefits of vaccines based on the health investment life course framework: A review of a broader approach to evaluate malaria vaccination

July 31, 2015 - 17:12 -- NOT Open Access
Author(s): 
Dagna Constenla
Reference: 
Vaccine, Volume 33, Issue 13, 24 March 2015, Pages 1527-1540

We describe a framework that measures the impact of a health policy decision on government accounts over many generations. The methodological issues emerging from this approach are illustrated with an example from a recently completed health investment life course analysis of malaria vaccination in Ghana.

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Structural Analysis of the Synthetic Duffy Binding Protein (DBP) Antigen DEKnull Relevant for Plasmodium vivax Malaria Vaccine Design

March 30, 2015 - 17:19 -- Open Access
Author(s): 
Edwin Chen, Nichole D. Salinas, Francis B. Ntumngia, John H. Adams, Niraj H. Tolia
Reference: 
PLoS Negl Trop Dis 9(3): e0003644

The Plasmodium vivax vaccine candidate Duffy Binding Protein (DBP) is a protein necessary for P. vivax invasion of reticulocytes.

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High levels of IgG3 anti ICB2-5 in Plasmodium vivax-infected individuals who did not develop symptoms

August 29, 2013 - 09:07 -- Open Access
Author(s): 
Versiani FG, Almeida ME, Melo GC, Versiani FO, Orlandi PP, Mariúba LA, Soares LA, Souza LP, da Silva Balieiro AA, Monteiro WM, Costa FT, del Portillo HA, Lacerda MV, Nogueira PA
Reference: 
Malaria Journal 2013, 12:294 (27 August 2013)
MalariaWorld

The study findings illustrate the importance of IgG3 associated to 2-months of symptomless in P. vivax infected individuals and open perspectives for the rationale of malaria vaccine designs capable to sustain high levels of IgG3 against polymorphic malaria antigens.

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Synergism from combinations of infection-blocking malaria vaccines

August 14, 2013 - 10:47 -- Open Access
Author(s): 
White MT, Smith DL
Reference: 
Malaria Journal 2013, 12:280 (8 August 2013)
MalariaWorld

Plasmodium falciparum infections present novel challenges for vaccine development, including parasite replication dynamics not previously encountered for viral pathogens, and enormous diversity in target antigens.

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NOT Open Access | Inhibitory Humoral Responses to the Plasmodium falciparum Vaccine Candidate EBA-175 Are Independent of the Erythrocyte Invasion Pathway

July 31, 2013 - 09:34 -- NOT Open Access
Author(s): 
Aida S. Badiane, Amy K. Bei, Manoj T. Duraisingh, et al.
Reference: 
Clin Vaccine Immunol August 2013 vol. 20 no. 8 1238-1245
MalariaWorld

Plasmodium falciparum utilizes multiple ligand-receptor interactions for invasion.

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NOT Open Access | An Essential Role for C5aR Signaling in the Optimal Induction of a Malaria-Specific CD4+ T Cell Response by a Whole-Killed Blood-Stage Vaccine

June 26, 2013 - 09:38 -- NOT Open Access
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Author(s): 
Taiping Liu, Guilian Xu, Bo Guo, Yong Fu, Yuan Qiu, Yan Ding, Hong Zheng, Xiaolan Fu, Yuzhang Wu, and Wenyue Xu
Reference: 
The Journal of Immunology July 1, 2013 vol. 191 no. 1 178-186
MalariaWorld

The protective immunity induced by the whole-killed parasite vaccine against malarial blood-stage infection is dependent on the CD4+ T cell response.

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Puf Mediates Translation Repression of Transmission-Blocking Vaccine Candidates in Malaria Parasites

April 22, 2013 - 12:24 -- Open Access
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Author(s): 
Jun Miao, Qi Fan, Daniel Parker, Xiaolian Li, Jianyong Li, Liwang Cui
Reference: 
PLoS Pathog 9(4): e1003268
MalariaWorld

Translational control of gene expression plays an essential role in development

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A mathematical model of the impact of present and future malaria vaccines

April 18, 2013 - 06:57 -- Open Access
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Author(s): 
Wenger EA, Eckhoff PA
Reference: 
Malaria Journal 2013, 12:126 (15 April 2013)
MalariaWorld

The maximum-impact setting is one in which the impact of increasing bed net coverage has saturated, vector feeding is primarily outdoors, and transmission is just above the threshold where small perturbations from a vaccine intervention result in large community benefits.

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NOT Open Access | Young Lives Lost as B Cells Falter: What We Are Learning About Antibody Responses in Malaria

March 27, 2013 - 08:20 -- NOT Open Access
Author(s): 
Silvia Portugal, Susan K. Pierce, and Peter D. Crompton
Reference: 
The Journal of Immunology April 1, 2013 vol. 190 no. 7 3039-3046
MalariaWorld

Plasmodium falciparum malaria remains a major public health threat for which there is no licensed vaccine.

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