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Artemisinin

Open Access | Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis

October 21, 2011 - 10:06 -- Patrick Sampao
Author(s): 
Liu R, Dong H, Guo Y, Zhao Q, Jiang M
Reference: 
Parasites & Vectors 2011, 4:201 (17 October 2011)

MalariaWorldIn this article, we conducted a systematic review and meta-analysis to evaluate the antischistosomal efficacy of different medication strategies including monotherapy or combination therapies of these drugs.

 

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Open Access | In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling

October 13, 2011 - 07:26 -- Kabogo Ndegwa
Author(s): 
Becker JV, van der Merwe MM, Van Brummelen AC, Pillay P, Crampton BG, Mmutlane EM, Parkinson C, van Heerden FR, Crouch NR, Smith PJ, Mancama DT, Maharaj VJ
Reference: 
Malaria Journal 2011, 10:295 (11 October 2011)

MalariaWorldThe novel mode of action of dehydrobrachylaenolide, detected during these studies, will play an ongoing role in advancing anti- plasmodial drug discovery efforts.

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Open Access | Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration

September 21, 2011 - 13:14 -- Kabogo Ndegwa
Author(s): 
Carrie A Morris, Stephan Duparc, Isabelle Borghini-Fuhrer, Donald Jung, Chang-Sik Shin, Lawrence Fleckenstein
Reference: 
Malaria Journal 2011, 10:263 (13 September 2011)

Artesunate (AS) is a clinically versatile artemisinin derivative utilized for the treatment of mild to severe malaria infection.

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Antiplasmodial activity of artecyclopentyl mether a new artemisinin derivative and its effect on pathogenesis in Plasmodium yoelii nigeriensis infected mice

September 21, 2011 - 07:26 -- Kabogo Ndegwa
Author(s): 
Jyoti Agarwal, Suriya Pratap Singh, Debabrata Chanda, Dnyaneshwar Umrao Bawankule, Rajendra Singh Bhakuni & Anirban Pal
Reference: 
Parasitology Research, Volume 109, Number 4, 1003-1008, DOI: 10.1007/s00436-011-2344-1

In an effort to evaluate novel derivatives from artemisinin, possessing potential antimalarial activity, a new derivative artecyclopentyl mether (CPM-1) was derivatized and evaluated for its dose-dependent efficacy in Plasmodium yoelii nigeriensis infected mice.

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Design and Evaluation of Primaquine-Artemisinin Hybrids as a Multistage Antimalarial Strategy

September 21, 2011 - 06:39 -- Kabogo Ndegwa
Author(s): 
Rita Capela, Ghislain G. Cabal, Philip J. Rosenthal, Jiri Gut, Maria M. Mota, Rui Moreira, Francisca Lopes, and Miguel Prudêncio
Reference: 
Antimicrobial Agents and Chemotherapy, October 2011,p. 4698-4706, Vol. 55, No. 10

It is widely accepted that the struggle against malaria depends on the development of new strategies to fight infection.

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Genomewide Scan Reveals Amplification of mdr1 as a Common Denominator of Resistance to Mefloquine, Lumefantrine, and Artemisinin in Plasmodium chabaudi Malaria Parasites

September 21, 2011 - 06:27 -- Kabogo Ndegwa
Author(s): 
Sofia Borges, Pedro Cravo, Alison Creasey, Richard Fawcett, Katarzyna Modrzynska, Louise Rodrigues, Axel Martinelli, and Paul Hunt
Reference: 
Antimicrobial Agents and Chemotherapy, October 2011,p. 4858-4865, Vol. 55, No. 10

Multidrug-resistant Plasmodium falciparum malaria parasites pose a threat to effective drug control, even to artemisinin-based combination therapies (ACTs).

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Open Access | Protein-based signatures of functional evolution in Plasmodium falciparum

September 15, 2011 - 15:10 -- Patrick Sampao
Author(s): 
Kate B Gardner, Ipsita Sinha , Leyla Y Bustamante , Nicholas PJ Day, Nicholas J White and Charles J Woodrow
Reference: 
BMC Evolutionary Biology 2011, 11:257

Against this tide of genetic drift, polymorphisms mediating functional change stand out to such an extent that evolutionary context provides a useful signal for identifying the molecular basis of drug resistance in malaria parasites, a finding that is of relevance to both genome-wide and candidate gene studies in this genus.

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Comment: Text messaging to improve adherence to malaria guidelines

September 1, 2011 - 12:15 -- Patrick Sampao
Author(s): 
Bruno Moonen, Justin M Cohen
Reference: 
The Lancet, Volume 378, 27 August 2011-2 September 2011, Pages 750-752

In The Lancet, Dejan Zurovac and colleagues4 present encouraging results from a randomised controlled trial in Kenya that used mobile-phone text messaging to remind health workers to adhere to national treatment guidelines.

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Open Access | Randomized trials of artemisinin-piperaquine, dihydroartemisinin-piperaquine phosphate and artemether-lumefantrine for the treatment of multi-drug resistant falciparum malaria in Cambodia-Thailand border area

August 16, 2011 - 09:21 -- Kabogo Ndegwa
Author(s): 
Song J, Socheat D, Tan B, Seila S, Xu Y, Ou F, Sokunthea S, Sophorn L, Zhou C, Deng C, Wang Q, Li G
Reference: 
Malaria Journal 2011, 10:231 (10 August 2011)

AP, DHP and AL all remained efficacious treatments for the treatment of falciparum malaria in Cambodia-Thailand border area.

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Open Access | Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription

August 8, 2011 - 11:55 -- Patrick Sampao
Author(s): 
Mok S, Imwong M, Bozdech Z, et al.
Reference: 
BMC Genomics 2011, 12:391 (3 August 2011)

To identify key features associated with the delayed parasite clearance phenotype, we employed DNA microarrays to profile the physiological gene expression pattern of the resistant isolates.

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