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Artemisinin

Synthetic Peroxides as Potent Antimalarials. News and Views

February 22, 2012 - 14:46 -- Patrick Sampao
Author(s): 
W. Jefford, Charles
Reference: 
Current Topics in Medicinal Chemistry, Volume 12, Number 5, March 2012 , pp. 373-399(27)

MalariaWorldThe present review describes the development of synthetic cyclic peroxides, which are designed to surpass the antimalarial activity of the lead molecule, the natural product (+)-artemisinin and some of its C10 derivatives.

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The Medicinal Chemistry of Novel Approaches for the Treatment of Malaria

February 22, 2012 - 14:16 -- Patrick Sampao
Author(s): 
J. Meyers, Marvin
Reference: 
Current Topics in Medicinal Chemistry, Volume 12, Number 5, March 2012 , pp. 371-372(2)

MalariaWorldThe introduction of artemisinin and artemisinin combination therapies (ACTs) in 2005 has begun to reverse the trend. While this is a good sign, there have been reports of resistance to artemisinin in Southeast Asia [2].

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Open Access | Editorial: How Do We Best Diagnose Malaria in Africa?

February 3, 2012 - 14:01 -- Patrick Sampao
Author(s): 
Philip J. Rosenthal
Reference: 
Am J Trop Med Hyg 2012 86:192-193

MalariaWorldIn this regard, the advent of rapid diagnostic tests (RDTs) for malaria is an important advance. Multiple immunochromatographic tests, incorporating a number of different parasite antigens and produced by many different manufacturers, are now available.

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Clinical Study: Risk Factors for Gametocyte Carriage in Uncomplicated Falciparum Malaria in Children before and after Artemisinin-Based Combination Treatments

January 19, 2012 - 15:19 -- Patrick Sampao
Author(s): 
Akintunde Sowunmi, Titilope M. Okuboyejo, Grace O. Gbotosho, Christian T. Happi
Reference: 
Chemotherapy 2011;57:497-504

MalariaWorldThe risk factors associated with gametocytaemia at presentation and after ACTs were evaluated in 835 children assigned to artesunate, artesunate-amodiaquine, artesunate-mefloquine or artemether-lumefantrine.

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Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

January 18, 2012 - 07:04 -- Kabogo Ndegwa
Author(s): 
Patrick J. Westfall, Douglas J. Pitera, Chris J. Paddon, et al.
Reference: 
PNAS January 17, 2012 vol. 109 no. 3 E111-E118

MalariaWorldMalaria, caused by Plasmodium sp, results in almost one million deaths and over 200 million new infections annually.

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Open Access | The use of paediatric artemisinin combinations in sub-Saharan Africa: a snapshot questionnaire survey of health care personnel

December 15, 2011 - 15:28 -- Patrick Sampao
Author(s): 
Agnandji ST, Kurth F, Ramharter M, et al.
Reference: 
Malaria Journal 2011, 10:365 (14 December 2011)

http://www.pnas.org/content/108/50/20113.abstractThis snapshot questionnaire survey aimed to provide an overview on the current routine practices for the availability and use P-ACT as anti-malarial treatment for young children in sub-Saharan Africa.

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Open Access | Prescription practices and availability of artemisinin monotherapy in India: where do we stand?

December 15, 2011 - 14:50 -- Patrick Sampao
Author(s): 
Mishra N, Anvikar AR, Shah NK, Kamal V, Sharma S, Srivastava H, Das M, Pradhan K, Kumar H, Gupta YK, Gupta P, Dash A, Valecha N
Reference: 
Malaria Journal 2011, 10:360 (13 December 2011)

MalariaWorldThis study resulted in notifications to all state drug controllers in India to withdraw the oral artemisinin formulations from the market. In 2010, artesunate + sulphadoxine-pyrimethamine became the universal first-line treatment for confirmed Plasmodium falciparum malaria and was deployed at full scale.

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Generation of the potent anti-malarial drug artemisinin in tobacco

December 14, 2011 - 08:00 -- Kabogo Ndegwa
Author(s): 
Moran Farhi, Elena Marhevka, Julius Ben-Ari, Anna Algamas-Dimantov, Zhuobin Liang, Vardit Zeevi, Orit Edelbaum, Ben Spitzer-Rimon, Hagai Abeliovich, Betty Schwartz, Tzvi Tzfira and Alexander Vainstein
Reference: 
Nature Biotechnology, Volume: 29,Pages: 1072–1074 Year published:(2011)

MalariaWorldThe emergence of multidrug-resistant strains of Plasmodium spp., the etiological agent of malaria, constitutes a major threat to controlling the disease1, 2.

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Malaria morbidity and pyrethroid resistance after the introduction of insecticide-treated bednets and artemisinin-based combination therapies: a longitudinal study

November 22, 2011 - 14:12 -- Patrick Sampao
Author(s): 
Jean-François Trape, Adama Tall, Cheikh Sokhna, et al.
Reference: 
The Lancet Infectious Diseases, Volume 11, Issue 12, December 2011, Pages 925-932

MalariaWorldWe did a longitudinal study of inhabitants of Dielmo village, Senegal, between January, 2007, and December, 2010. We monitored the inhabitants for fever during this period and we treated malaria attacks with artesunate plus amodiaquine.

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Malaria drug resistance: new observations and developments.

October 27, 2011 - 13:35 -- Patrick Sampao
Author(s): 
Sá JM, Chong JL, Wellems TE
Reference: 
Essays Biochem. 2011 Oct 24;51:137-60.

MalariaWorldWe review some contributions that early efficacy studies of antimalarial treatment brought to clinical pharmacology, including convincing documentation of atebrine-resistant malaria in the 1940s, prior to the launching of what soon became first-choice antimalarials, chloroquine and amodiaquine.

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