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Artemisinin

Ex vivo drug sensitivity profiles of Plasmodium falciparum field isolates from Cambodia and Thailand, 2005 to 2010, determined by a histidinerich protein-2 assay

June 20, 2012 - 09:03 -- Kabogo Ndegwa
Author(s): 
Tyner SD, Lon C, Walsh DS, et al.
Reference: 
Malaria Journal 2012, 11:198 (13 June 2012)

MalariaWorldWestern Cambodia is associated with sustained reductions in anti-malarial drug susceptibility, including the artemisinins, with possible emergence, or spread, to northern Cambodia.

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Not Open Access | Malaria drug resistance: new observations and developments.

June 18, 2012 - 15:18 -- Patrick Sampao
Author(s): 
Sá JM, Chong JL, Wellems TE.
Reference: 
Essays Biochem. 2011;51:137-60.

MalariaWorldWe review some contributions that early efficacy studies of antimalarial treatment brought to clinical pharmacology, including convincing documentation of atebrine-resistant malaria in the 1940s, prior to the launching of what soon became first-choice antimalarials, chloroquine and amodiaquine.

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Efficacy of artemether-lumefantrine, the nationally-recommended artemisinin combination for the treatment of uncomplicated falciparum malaria, in southern Laos

June 13, 2012 - 14:59 -- Patrick Sampao
Author(s): 
Mayxay M, Khanthavong M, Chanthongthip O, Imwong M, Pongvongsa T, Hongvanthong B, Phompida S, Vanisaveth V, White NJ, Newton PN
Reference: 
Malaria Journal 2012, 11:184 (8 June 2012)

MalariaWorldOf 630 patients with P. falciparum enrolled in the trial of thiamin treatment, 549 (87%, 357 children [less than or equal to]15 years and 192 adults) were included in this study.

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NOT Open Access | Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study

May 29, 2012 - 12:50 -- Patrick Sampao
Author(s): 
Aung Pyae Phyo, Standwell Nkhoma, François Nosten, et al.
Reference: 
The Lancet, Volume 379, Issue 9830, 26 May–1 June 2012, Pages 1960-1966

MalariaWorldIn malaria clinics located along the northwestern border of Thailand, we measured six hourly parasite counts in patients with uncomplicated hyperparasitaemic falciparum malaria (≥4% infected red blood cells) who had been given various oral artesunate-containing regimens since 2001.

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Open Access | Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections

May 2, 2012 - 14:27 -- Kabogo Ndegwa
Author(s): 
Pillai DR, Lau R, Khairnar K, Lepore R, Via A, Staines HM, Krishna S
Reference: 
Malaria Journal 2012, 11:131 (27 April 2012)

MalariaWorldThese findings were further explored in molecular modelling experiments that suggest mutations in pfatp6 are unlikely to affect differential binding of artemisinins at their proposed site, whereas there may be differences in such binding associated with mutations in pfmdr1.

Open Access | Examining equity in access to long-lasting insecticide nets and artemisinin-based combination therapy in Anambra state, Nigeria.

May 1, 2012 - 13:27 -- Patrick Sampao
Author(s): 
Mbachu CO, Onwujekwe OE, Uzochukwu BS, Uchegbu E, Oranuba J, Ilika AL
Reference: 
BMC Public Health 2012, 12:315 (30 April 2012)

MalariaWorldA questionnaire was used to collect data from randomly selected households in 19 local government areas of the State. Selected households had a pregnant woman and/or a child less than 5 years.

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Hydroxyl mechanism of the antimalarial effect of artemisinin and its analogs

April 17, 2012 - 14:46 -- Patrick Sampao
Author(s): 
E. T. Denisov and T. G. Denisova
Reference: 
Russian Chemical Bulletin, 2011, Volume 60, Number 7, Pages 1421-1435

MalariaWorldKinetic schemes for the intramolecular oxidation of four artemisinin analogs, which are used as drugs against malaria, were developed.

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Comparative Efficacies of Artemisinin Combination Therapies in Plasmodium falciparum Malaria and Polymorphism of pfATPase6, pfcrt, pfdhfr, and pfdhps Genes in Tea Gardens of Jalpaiguri District, India

April 13, 2012 - 13:46 -- Patrick Sampao
Author(s): 
Pabitra Saha, Subhasish K. Guha, Ardhendu K. Maji, et al.
Reference: 
Antimicrob. Agents Chemother. May 2012 vol. 56 no. 5 2511-2517

MalariaWorldA total of 157 patients with P. falciparum monoinfection were recruited and randomized into three study groups (AS-SP, AM-LF, and AS-MQ). All patients were followed up for 42 days to study the clinical and parasitological responses according to the WHO protocol (2009). We assessed the polymorphism of the pfATPase6, pfcrt, pfdhfr, and pfdhps genes by the DNA-sequencing method. The

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Open Access | Priority setting for the implementation of artemisinin-based combination therapy policy in Tanzania: evaluation against the accountability for reasonableness framework

March 19, 2012 - 15:11 -- Patrick Sampao
Author(s): 
Amani Thomas Mori and Eliangiringa Amos Kaale
Reference: 
Implementation Science 2012, 7:18

MalariaWorldIn our understanding, this is the first study to evaluate priority-setting decisions for new drugs in Tanzania against the accountability for reasonableness framework.

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Open Access | No Evidence for Spread of Plasmodium falciparum Artemisinin Resistance to Savannakhet Province, Southern Laos

March 9, 2012 - 14:23 -- Patrick Sampao
Author(s): 
Mayfong Mayxay, Maniphone Khanthavong, Paul N. Newton, et al.
Reference: 
Am J Trop Med Hyg 2012 86:403-408

MalariaWorldWe conducted an open-label, randomized clinical trial to assess parasite clearance times (PCT) and the efficacy of 4 mg/kg (group 1, n = 22) and 2 mg/kg (group 2, n = 22) of oral artesunate for three days followed by artemether-lumefantrine in patients with uncomplicated Plasmodium falciparum malaria at Xepon Interdistrict Hospital, Savannakhet Province in southern Laos.

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