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Artemisinin

Safety monitoring of artemisinin combination therapy through a national pharmacovigilance system in an endemic malaria setting

February 11, 2013 - 16:03 -- Open Access
Author(s): 
Thiam S, Ndiaye J, Diallo I, Gatonga P, Fall FB, Diallo NE, Faye B, Diouf ML, Ndiop M, Diouf MB, Gaye O, Thior M
Reference: 
Malaria Journal 2013, 12:54 (5 February 2013)
MalariaWorld

In this framework, an anti-malarial pharmacovigilance plan was developed and implemented in all public health services. This study investigated the occurrence of Adverse Drug Events (ADEs) after ACT.

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NOT Open Access | Reduced Artemisinin Susceptibility of Plasmodium falciparum Ring Stages in Western Cambodia

January 24, 2013 - 14:28 -- NOT Open Access
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Author(s): 
Benoit Witkowski, Nimol Khim, Didier Menard, et al.
Reference: 
Antimicrob. Agents Chemother. February 2013 vol. 57 no. 2 914-923
MalariaWorld

The declining efficacy of artemisinin derivatives against Plasmodium falciparum in western Cambodia is a major concern.

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Not Open Access | Research review paper: Microbial transformation of antimalarial terpenoids

October 17, 2012 - 15:58 -- Patrick Sampao
Author(s): 
Igor A. Parshikov, Alexander I. Netrusov, John B Sutherland
Reference: 
Biotechnology Advances, Volume 30, Issue 6, November–December 2012, Pages 1516–1523, Special issue on ACB 2011

MalariaWorldThe fungal and bacterial transformation of terpenoids derived from plant essential oils, especially the sesquiterpenoid artemisinin from Artemisia annua, has produced several new candidate drugs for the treatment of malaria.

An Image-Based Drug Susceptibility Assay Targeting the Placental Sequestration of Plasmodium falciparum-Infected Erythrocytes

September 3, 2012 - 07:56 -- Kabogo Ndegwa
Author(s): 
Min-Je Ku, Fernando de M. Dossin, Michael A. E. Hansen, Auguste Genovesio, Lawrence Ayong, Lucio H. Freitas-Junior
Reference: 
PLoS ONE 7(8): e41765

MalariaWorldPlacental malaria is a significant cause of all malaria-related deaths globally for which no drugs have been developed to specifically disrupt its pathogenesis.

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Therapeutic efficacy of artesunate in the treatment of uncomplicated Plasmodium falciparum malaria and anti-malarial, drug-resistance marker polymorphisms in populations near the China- Myanmar border

August 22, 2012 - 06:40 -- Kabogo Ndegwa
Author(s): 
Huang F, Tang L, Yang H, Zhou S, Sun X, Liu H
Reference: 
Malaria Journal 2012, 11:278 (16 August 2012)

MalariaWorldPlasmodium falciparum infection was associated with slow parasite clearance and suspected artemisinin resistance at the China-Myanmar border area.

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Artemisinin-Resistant Malaria: Research Challenges, Opportunities, and Public Health Implications

August 2, 2012 - 12:14 -- Patrick Sampao
Author(s): 
Rick M. Fairhurst, Gaurvika M. L. Nayyar, Arjen M. Dondorp, et al.
Reference: 
Am J Trop Med Hyg 2012 87:231-241

MalariaWorldInspired by this conference, this review summarizes novel findings and perspectives on artemisinin resistance, approaches for translating research data into relevant public health information, and opportunities for interdisciplinary collaboration to combat artemisinin resistance.

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NOT Open Access | Harmine Is a Potent Antimalarial Targeting Hsp90 and Synergizes with Chloroquine and Artemisinin

July 24, 2012 - 11:54 -- Kabogo Ndegwa
Author(s): 
Dea Shahinas, Gregory MacMullin, Christan Benedict, Ian Crandall, and Dylan R. Pillai
Reference: 
Antimicrob. Agents Chemother. August 2012 vol. 56 no. 8 4207-4213

MalariaWorldPrevious studies have shown an antimalarial effect of total alkaloids extracted from leaves of Guiera senegalensis from Mali in West Africa.

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NOT Open Access | Synthesis, antimalarial activity and cytotoxicity of 10-aminoethylether derivatives of artemisinin

July 20, 2012 - 12:02 -- Kabogo Ndegwa
Author(s): 
Theunis T. Cloete, J. Wilma Breytenbach, Carmen de Kock, Peter J. Smith, Jaco C. Breytenbach, David D. N’Da
Reference: 
Bioorganic & Medicinal Chemistry, Volume 20, Issue 15, 1 August 2012, Pages 4701–4709

MalariaWorldIn this study, a series of 11 10-aminoethylether derivatives of artemisinin were synthesised and their antimalarial activity against both the chloroquine sensitive (D10) and resistant (Dd2) strains of Plasmodium falciparum was determined.

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No Evidence of Decreased Artemisinin Efficacy in a High-Transmission Malaria Setting in Mali

July 4, 2012 - 14:09 -- Patrick Sampao
Author(s): 
Caroline L. Ng and David A. Fidock
Reference: 
Am J Trop Med Hyg 2012 87:16-17

MalariaWorldOne major threat, however, comes from recent reports of emerging resistance to artemisinins, which was first documented in western Cambodia and more recently in northwestern Thailand.5–8 This region in Southeast Asia is of particular concern because it was the source of CQ and SP resistance that eventually migrated to Africa,9 raising concerns that artemisinin resistance may follow the same trajectory

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Repeated Artemisinin-Based Combination Therapies in a Malaria Hyperendemic Area of Mali: Efficacy, Safety, and Public Health Impact

July 4, 2012 - 12:36 -- Patrick Sampao
Author(s): 
Issaka Sagara, Bakary Fofana, Abdoulaye A. Djimde, et al.
Reference: 
Am J Trop Med Hyg 2012 87:50-56

MalariaWorldWe conducted a randomized trial comparing artemether-lumefantrine, artesunate plus amodiaquine (AS+AQ) and artesunate plus sulfadoxine-pyrimethamine (AS+SP) in patients 6 months of age and older with uncomplicated malaria in Mali from July 2005 to July 2007.

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