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medicinal plant

Antiplasmodial agents from the Bhutanese medicinal plant Corydalis calliantha

March 31, 2010 - 12:26 -- Patrick Sampao
Author(s): 
Phurpa Wangchuk, John B. Bremner, Samten, Roonglawan Rattanajak, Sumalee Kamchonwongpaisan
Reference: 
Phytotherapy Research, Volume 24, Issue 4, Date: April 2010, Pages: 481-485

The results thus support, at a molecular level, the clinical use of this plant in the Bhutanese traditional medicine and identified cheilanthifoline as a potential new antimalarial drug lead.

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Comparison of SYBR Green I-, PicoGreen-, and [3H]-hypoxanthine-based assays for in vitro antimalarial screening of plants from Nigerian ethnomedicine

March 17, 2010 - 10:38 -- Ingeborg van Schayk
Author(s): 
Oyindamola O. Abiodun, Grace O. Gbotosho, Edith O. Ajaiyeoba, Christian T. Happi, Sandra Hofer, Sergio Wittlin, Akin Sowunmi, Reto Brun & Ayoade M. J. Oduola
Reference: 
Parasitology Research, Volume 106, Number 4 / March, 2010 : 933-939

SG appears to be a cost-effective alternative for antimalarial drug screening and a viable technique that may facilitate antimalarial drug discovery process especially in developing countries.

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New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides

February 25, 2010 - 21:46 -- Kabogo Ndegwa
Author(s): 
Satoru Tamura, Bruno Kilunga Kubata, Syamsurizal, Sawako Itagaki, Toshihiro Horii, Muzele Kalulu Taba, Nobutoshi Murakami
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 5, 1 March 2010, Pages 1520-1523

A new phenylpropanoid conjugated iridoid together with four known congeners was isolated from Morinda morindoides, used for the therapy of malaria traditionally in some African countries, as anti-malarial principles through bioassay-guided separation.

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