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Pharmacology: Pharmacokinetics of Chloroquine and Monodesethylchloroquine in Pregnancy

February 25, 2010 - 20:54 -- Kabogo Ndegwa
Harin A. Karunajeewa, Sam Salman, Ivo Mueller, Francisca Baiwog, Servina Gomorrai, Irwin Law,1 Madhu Page-Sharp, Stephen Rogerson, Peter Siba, Kenneth F. Ilett, and Timothy M. E. Davis
Antimicrobial Agents and Chemotherapy, March 2010, Pages 1186-1192, Volume 54, No. 3

Reduced plasma concentrations of both CQ and DECQ could compromise both curative efficacy and posttreatment prophylactic properties in pregnant patients. Higher IPTp CQ doses may be desirable but could increase the risk of adverse hemodynamic effects.

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