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anti-malaria drug

Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug

March 25, 2010 - 20:12 -- Patrick Sampao
Jacob H. Rand, Xiao-Xuan Wu, Anthony S. Quinn, Anthony W. Ashton, Pojen P. Chen, James J. Hathcock, Harry A. M. Andree, and Douglas J. Taatjes
Blood, 18 March 2010, Vol. 115, No. 11, pp. 2292-2299.

In conclusion, HCQ reversed antiphospholipid-mediated disruptions of AnxA5 on PLBs and cultured cells, and in APS patient plasmas. These results support the concept of novel therapeutic approaches that address specific APS disease mechanisms.

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The blood parasite Haemoproteus reduces survival in a wild bird: a medication experiment

March 5, 2010 - 14:56 -- Ingeborg van Schayk
Josué Martínez-de la Puente1,*, Santiago Merino1, Gustavo Tomás1,2, Juan Moreno1, Judith Morales, Elisa Lobato, Sonia García-Fraile and Eduardo Jorge Belda
Biology Letters, Published online before print February 24, 2010

In this study we test for the effect of the antimalarial-drug primaquine on the survival probability of wild birds infected by the malaria-like parasite Haemoproteus.

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Therapeutic efficacy and effect on gametocyte carriage of an artemisinin and a non-based combination treatment in children with uncomplicated P. falciparum malaria, living in an area with high-level chloroquine resistance

February 15, 2010 - 13:10 -- Ingeborg van Schayk
Henrietta U. Okafor, Elvis N. Shu, and Tagbo Oguonu
ournal of Tropical Pediatrics Advance Access published online on February 8, 2010

We evaluate the therapeutic efficacy and effects on gametocyte carriage of Artemether–Lumefantrine (AL) and Amodiaquine–Sulfalene/Pyrimethamine (ASP) in children with P. falciparum malaria in an endemic area.

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