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anti-malaria drug

Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug

March 25, 2010 - 20:12 -- Patrick Sampao
Author(s): 
Jacob H. Rand, Xiao-Xuan Wu, Anthony S. Quinn, Anthony W. Ashton, Pojen P. Chen, James J. Hathcock, Harry A. M. Andree, and Douglas J. Taatjes
Reference: 
Blood, 18 March 2010, Vol. 115, No. 11, pp. 2292-2299.

In conclusion, HCQ reversed antiphospholipid-mediated disruptions of AnxA5 on PLBs and cultured cells, and in APS patient plasmas. These results support the concept of novel therapeutic approaches that address specific APS disease mechanisms.

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The blood parasite Haemoproteus reduces survival in a wild bird: a medication experiment

March 5, 2010 - 14:56 -- Ingeborg van Schayk
Author(s): 
Josué Martínez-de la Puente1,*, Santiago Merino1, Gustavo Tomás1,2, Juan Moreno1, Judith Morales, Elisa Lobato, Sonia García-Fraile and Eduardo Jorge Belda
Reference: 
Biology Letters, Published online before print February 24, 2010

In this study we test for the effect of the antimalarial-drug primaquine on the survival probability of wild birds infected by the malaria-like parasite Haemoproteus.

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Therapeutic efficacy and effect on gametocyte carriage of an artemisinin and a non-based combination treatment in children with uncomplicated P. falciparum malaria, living in an area with high-level chloroquine resistance

February 15, 2010 - 13:10 -- Ingeborg van Schayk
Author(s): 
Henrietta U. Okafor, Elvis N. Shu, and Tagbo Oguonu
Reference: 
ournal of Tropical Pediatrics Advance Access published online on February 8, 2010

We evaluate the therapeutic efficacy and effects on gametocyte carriage of Artemether–Lumefantrine (AL) and Amodiaquine–Sulfalene/Pyrimethamine (ASP) in children with P. falciparum malaria in an endemic area.

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