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Manadoperoxides A-D from the Indonesian Sponge Plakortis cfr. simplex. Further Insights on the Structure-Activity Relationships of Simple 1,2-Dioxane Antimalarials

June 9, 2010 - 08:01 -- Kabogo Ndegwa
Author(s): 
C Fattorusso, M Persico, B Calcinai, C Cerrano, S Parapini, D Taramelli, E Novellino, A Romano, F Scala, E Fattorusso, O Taglialatela-Scafati
Reference: 
J. Nat. Prod. June 3, 2010

The new endoperoxyketal polyketides manadoperoxides A−D (2−5) have been isolated from the Indonesian sponge Plakortis cfr. simplex and their stereostructures established by means of spectroscopic data and semisynthetic transformations.

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