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Characterization and optimization of the haemozoin-like crystal (HLC) assay to determine Hz inhibiting effects of anti-malarial compounds

October 14, 2015 - 08:49 -- Open Access
Carolina Tempera, Ricardo Franco, Carlos Caro, Vânia André, Peter Eaton, Peter Burke, Thomas Hänscheid
Malaria Journal 2015, 14:403 (12 October 2015)

The HLC assay provides data on inhibiting properties of compounds.

Medical Treatment: 

Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: Synthesis, antiplasmodial activity, and cytotoxicity

February 13, 2010 - 09:13 -- Kabogo Ndegwa
João Lavrado, Alexandra Paulo, Jiri Gut, Philip J. Rosenthal and Rui Moreira
Bioorganic & Medicinal Chemistry Letters, Volume 18, Issue 4, 15 February 2008, Pages 1378-1381

A series of cryptolepine derivatives has been synthesized through the incorporation of short basic side-chains in the C-11 position of the 10H-indolo[3,2-b]quinoline scaffold.

Medical Condition: 
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