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Effects of the anti-malarial compound cryptolepine and its analogues in human lymphocytes and sperm in the Comet assay

October 31, 2011 - 14:37 -- Patrick Sampao
Rajendran C. Gopalan, Esra Emerce, Colin W. Wright, Bensu Karahalil, Ali E. Karakaya, Diana Anderson
Toxicology Letters, Volume 207, Issue 3, 15 December 2011, Pages 322-325

MalariaWorldIn the context of antimalarial drug development, the data suggest that all cryptolepine compounds and in particular 2,7-dibromocryptolepine cause DNA damage and therefore may not be suitable for pre clinical development as antimalarial agents.

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Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: Synthesis, antiplasmodial activity, and cytotoxicity

February 13, 2010 - 09:13 -- Kabogo Ndegwa
João Lavrado, Alexandra Paulo, Jiri Gut, Philip J. Rosenthal and Rui Moreira
Bioorganic & Medicinal Chemistry Letters, Volume 18, Issue 4, 15 February 2008, Pages 1378-1381

A series of cryptolepine derivatives has been synthesized through the incorporation of short basic side-chains in the C-11 position of the 10H-indolo[3,2-b]quinoline scaffold.

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