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Open Access | Drug-Drug Interaction Analysis of Pyronaridine/Artesunate and Ritonavir in Healthy Volunteers

March 9, 2012 - 14:36 -- Patrick Sampao
Carrie A. Morris, Luis Lopez-Lazaro, Donald Jung, Janthima Methaneethorn, Stephan Duparc, Isabelle Borghini-Fuhrer, Rolf Pokorny, Chang-Sik Shin and Lawrence Fleckenstein
Am J Trop Med Hyg 2012 vol. 86 no. 3 489-495

MalariaWorldA multiple dose, parallel group study was conducted to assess for a drug-drug interaction between the pyronaridine/artesunate (PA) combination antimalarial and ritonavir.


Pharmacokinetic interactions between ritonavir and quinine in healthy volunteers following concurrent administration

February 11, 2010 - 13:39 -- Kabogo Ndegwa
Julius O. Soyinka, Cyprian O. Onyeji, Sharon I. Omoruyi, Adegbenga R. Owolabi, Pullela V. Sarma, James M. Cook
British Journal of Clinical Pharmacology, Volume 69, Issue 3, March 2010, Pages: 262-270

Downward dosage adjustment of quinine appears necessary when concurrently administered with ritonavir.

Medical Treatment: 
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