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ritonavir

Open Access | Drug-Drug Interaction Analysis of Pyronaridine/Artesunate and Ritonavir in Healthy Volunteers

March 9, 2012 - 14:36 -- Patrick Sampao
Author(s): 
Carrie A. Morris, Luis Lopez-Lazaro, Donald Jung, Janthima Methaneethorn, Stephan Duparc, Isabelle Borghini-Fuhrer, Rolf Pokorny, Chang-Sik Shin and Lawrence Fleckenstein
Reference: 
Am J Trop Med Hyg 2012 vol. 86 no. 3 489-495

MalariaWorldA multiple dose, parallel group study was conducted to assess for a drug-drug interaction between the pyronaridine/artesunate (PA) combination antimalarial and ritonavir.

Person: 
volunteers
Medical Treatment: 
antimalarial
ritonavir
pyronaridine-artesunate

Pharmacokinetic interactions between ritonavir and quinine in healthy volunteers following concurrent administration

February 11, 2010 - 13:39 -- Kabogo Ndegwa
Author(s): 
Julius O. Soyinka, Cyprian O. Onyeji, Sharon I. Omoruyi, Adegbenga R. Owolabi, Pullela V. Sarma, James M. Cook
Reference: 
British Journal of Clinical Pharmacology, Volume 69, Issue 3, March 2010, Pages: 262-270

Downward dosage adjustment of quinine appears necessary when concurrently administered with ritonavir.

Person: 
volunteer
Medical Condition: 
malaria
HIV
pharmacokinetic interaction
Medical Treatment: 
quinine
ritonavir
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