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immunopathology

Control of immunopathology during Plasmodium infection by hepcidin

December 28, 2011 - 13:05 -- Patrick Sampao
Author(s): 
Ivo Marguti
Reference: 
Medical Hypotheses, Volume 78, Issue 2, February 2012, Pages 250-253

MalariaWorldHerein the hypothesis that hemoglobinopathies afford protection against severe forms of malaria by limiting exacerbated immune activation, via a mechanism that involves low hepcidin expression, is discussed.

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Open Access | Invited Speaker Presentation: Immunopathology and dexamethasone therapy in a new model for malaria-associated acute respiratory distress syndrome

November 3, 2010 - 14:16 -- Patrick Sampao
Author(s): 
Philippe E Van den Steen, Nathalie Geurts, Katrien Deroost, Ilse Van Aelst, Sebastien Verhenne, Hubertine Heremans, Jo Van Damme, Ghislain Opdenakker
Reference: 
Malaria Journal 2010, 9(Suppl 2):I13 (20 October 2010)

To develop a new animal model for MA-ARDS, mice were infected with Plasmodium berghei NK65, and the development of MA-ARDS was characterized by increased lung weight, edema, leukocyte infiltration and hemorrhages (Figure 1).

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Essential Role for IL-27 Receptor Signaling in Prevention of Th1-Mediated Immunopathology during Malaria Infection

August 5, 2010 - 11:56 -- Kabogo Ndegwa
Author(s): 
Emily Gwyer Findlay, Rachel Greig, Jason S. Stumhofer, Julius C. R. Hafalla, J. Brian de Souza, Christiaan J. Saris, Christopher A. Hunter, Eleanor M. Riley, and Kevin N. Couper
Reference: 
The Journal of Immunology, 2010, 185, 2482 -2492

Successful resolution of malaria infection requires induction of proinflammatory immune responses that facilitate parasite clearance; however, failure to regulate this inflammation leads to immune-mediated pathology.

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Immunopathology and Dexamethasone Therapy in a New Model for Malaria-Associated Acute Respiratory Distress Syndrome

January 31, 2010 - 13:16 -- Ingeborg van Schayk
Author(s): 
Phillippe E Van den Steen, Nathalie Geurts, Katrien Deroost, Ilse Van Aelst, Sebastien Verhenne, Hubertine Heremans, Jo Van Damme, and Ghislain Opdenakker
Reference: 
Am. J. Respir. Crit. Care Med. 2010, Published ahead of print on January 21, 2010

The finding that high doses of dexamethasone cured MA-ARDS suggests that it might be more effective against MA-ARDS than it was in the clinical trials for cerebral malaria.

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