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dexamethasone

Open Access | Invited Speaker Presentation: Immunopathology and dexamethasone therapy in a new model for malaria-associated acute respiratory distress syndrome

November 3, 2010 - 14:16 -- Patrick Sampao
Author(s): 
Philippe E Van den Steen, Nathalie Geurts, Katrien Deroost, Ilse Van Aelst, Sebastien Verhenne, Hubertine Heremans, Jo Van Damme, Ghislain Opdenakker
Reference: 
Malaria Journal 2010, 9(Suppl 2):I13 (20 October 2010)

To develop a new animal model for MA-ARDS, mice were infected with Plasmodium berghei NK65, and the development of MA-ARDS was characterized by increased lung weight, edema, leukocyte infiltration and hemorrhages (Figure 1).

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Immunopathology and Dexamethasone Therapy in a New Model for Malaria-Associated Acute Respiratory Distress Syndrome

January 31, 2010 - 13:16 -- Ingeborg van Schayk
Author(s): 
Phillippe E Van den Steen, Nathalie Geurts, Katrien Deroost, Ilse Van Aelst, Sebastien Verhenne, Hubertine Heremans, Jo Van Damme, and Ghislain Opdenakker
Reference: 
Am. J. Respir. Crit. Care Med. 2010, Published ahead of print on January 21, 2010

The finding that high doses of dexamethasone cured MA-ARDS suggests that it might be more effective against MA-ARDS than it was in the clinical trials for cerebral malaria.

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