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ACTs

Exploring health providers' and community perceptions and experiences with malaria tests in South-East Nigeria: a critical step towards appropriate treatment

November 12, 2012 - 09:36 -- Open Access
Author(s): 
Ezeoke OP, Ezumah NN, Chandler CC, Magham-Jefferies LJ, Onwujekwe OE, Wiseman V, Uzochukwu BS
Reference: 
Malaria Journal 2012, 11:368 (6 November 2012)
MalariaWorld

The results highlight important areas of intervention to promote appropriate malaria treatment.

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Open Access | Impact of combining intermittent preventive treatment with home management of malaria in children less than 10 years in a rural area of Senegal: a cluster randomized trial

December 15, 2011 - 15:48 -- Kabogo Ndegwa
Author(s): 
Tine RC, Faye B, Ndour CT, Ndiaye JL, Ndiaye M, Bassene C, Magnussen P, Bygbjerg IC, Sylla K, Ndour JD, Gaye O
Reference: 
Malaria Journal 2011, 10:358 (13 December 2011)

http://www.pnas.org/content/108/50/20113.abstractCombining IPTc and HMM can provide significant additional benefit in preventing clinical episodes of malaria as well as anaemia among children in Senegal.

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Open Access | Poor quality vital anti-malarials in Africa - an urgent neglected public health priority

December 15, 2011 - 15:28 -- Kabogo Ndegwa
Author(s): 
Newton PN, Green MD, Fernandez FM, et al.
Reference: 
Malaria Journal 2011, 10:352 (13 December 2011)

http://www.pnas.org/content/108/50/20113.abstractCriminals are producing diverse harmful anti-malarial counterfeits with important public health consequences.

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Antimalarial efficacy of piperaquine-based antimalarial combination therapies: facts and uncertainties

November 17, 2011 - 08:01 -- Kabogo Ndegwa
Author(s): 
Nicola Gargano, Fabio Cenci and Quique Bassat
Reference: 
Tropical Medicine & International Health, Volume 16, Issue 12, pages 1466–1473, December 2011

MalariaWorldPiperaquine is a bisquinoline antimalarial drug extensively used as monotherapy in China in the 1980s and subsequently included as one of the components of the artemisinin-based combination therapies (ACTs) in the 1990s.

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Open Access | A Head-to-Head Comparison of Four Artemisinin-Based Combinations for Treating Uncomplicated Malaria in African Children: A Randomized Trial

November 9, 2011 - 12:59 -- Kabogo Ndegwa
Author(s): 
The Four Artemisinin-Based Combinations (4ABC) Study Group
Reference: 
PLoS Med 8(11): e1001119

MalariaWorldMalaria is a global public-health problem. Half the world's population is at risk of this mosquito-borne parasitic disease, which kills a million people (mainly children living in sub-Saharan Africa) every year.

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Plasmodium vivax treatments: what are we looking for?

October 26, 2011 - 14:08 -- Kabogo Ndegwa
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Author(s): 
Price, Ric N.; Douglas, Nicholas M.; Anstey, Nicholas M.; von Seidlein, Lorenz
Reference: 
C urrent Opinion in Infectious Diseases, December 2011 - Volume 24 - Issue 6 - p 578–585

MalariaWorldIn regions coendemic for P. vivax and P. falciparum, a unified treatment policy for malaria of any parasitological cause is likely to confer the greatest individual and public health benefit.

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Rational deployment of antimalarial drugs in Africa: should first-line combination drugs be reserved for paediatric malaria cases?

September 28, 2011 - 06:54 -- Kabogo Ndegwa
Author(s): 
Colinn J. Sutherland, Hamza Babiker, Margaret J. Mackinnon, Lisa Ranford-Cartwright, Badria Babiker El Sayed
Reference: 
Parasitology, Volume 138, Special Issue 12 - Symposia of the British Society for Parasitology Volume 47, October 2011, pp 1459 – 1468

Artemisinin-based combination therapy is exerting novel selective pressure upon populations of Plasmodium falciparum across Africa.

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Administrative practices of health professionals and use of artesunate–amodiaquine by community members for treating uncomplicated malaria in southern Ghana: implications for artemisinin-based combination therapy deployment

September 21, 2011 - 07:04 -- Kabogo Ndegwa
Author(s): 
Bethel Kwansa-Bentum, Irene Ayi, Takashi Suzuki, Joseph Otchere, Takashi Kumagai, William K. Anyan, Hiroko Asahi, Nobuaki Akao, Michael D. Wilson, Daniel A. Boakye and Nobuo Ohta
Reference: 
Tropical Medicine & International Health, Volume 16, Issue 10, pages 1215–1224, October 2011

Whereas the use of AS-AQ and AL are acceptable, the frequent use of dihydroartemisinin and artesunate monotherapy threatens the future of ACTs.

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Open Access | Evaluation and pharmacovigilance of projects promoting cultivation and local use of Artemisia annua for malaria

April 20, 2011 - 12:12 -- Kabogo Ndegwa
Author(s): 
Merlin L Willcox, Shelly Burton, Rosalia Oyweka, Rehema Namyalo, Simon Challand, Keith Lindsey
Reference: 
Malaria Journal 2011, 10:84 (11 April 2011)

Local cultivation and preparation of A. annua are feasible where growing conditions are appropriate.

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Open Access | Assessment of global reporting of adverse drug reactions for anti-malarials, including artemisinin-based combination therapy, to the WHO Programme for International Drug Monitoring

March 11, 2011 - 08:38 -- Kabogo Ndegwa
Author(s): 
Kuemmerle A, Dodoo AN, Olsson S, Van Erps J, Burri C, Lalvani PS
Reference: 
Malaria Journal 2011, 10:57 (9 March 2011)

Bringing together the competencies of national pharmacovigilance centres and various types of organizations in the NGO, academic and private sectors with global coordination to create short- and long-term solutions may help address the lag between rapidly growing ACT use and poor ADR reporting.

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